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  • 产品名称：Anti-CYP4F11 antibody (60-130) (STJ11104057)

  • 产品型号：STJ11104057
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CYP4F11 antibody (60-130) (STJ11104057)
详情介绍：
Host: Rabbit
Applications: IF
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Cytochrome P450 4f11 (60-130) is suitable for use in Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CYP4F11
Gene ID: 57834
Uniprot ID: CP4FB_HUMAN
Immunogen Region: 60-130
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 60-130 of human CYP4F11 (NP_001122404.1).
Immunogen Sequence: FWGHQGLVTPTEEGMKTLTQ LVTTYPQGFKLWLGPTFPLL ILCHPDIIRPITSASAAVAP KDMIFYGFLKP
Tissue Specificity Expressed mainly in human liver, followed by kidney, heart, and skeletal muscle.
Function A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and their oxygenated derivatives (oxylipins). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR.NADPH-ferrihemoprotein reductase). Catalyzes with high efficiency the oxidation of the terminal carbon (omega-oxidation) of 3-hydroxy fatty acids, such as 3-hydroxyhexadecanoic and 3-hydroxyoctadecanoic acids, likely participating in the biosynthesis of long-chain 3-hydroxydicarboxylic acids. Omega-hydroxylates and inactivates phylloquinone (vitamin K1), and menaquinone-4 (MK-4, a form of vitamin K2), both acting as cofactors in blood coagulation. Metabolizes with low efficiciency fatty acids, including (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) and its oxygenated metabolite 8-hydroxyeicosatetraenoic acid (8-HETE). Catalyzes N- and O-demethylation of drugs such as erythromycin, benzphetamine, ethylmorphine, chlorpromazine, imipramine and verapamil.
Protein Name Cytochrome P450 4f11
Cypivf11
3-Hydroxy Fatty Acids Omega-Hydroxylase Cyp4f11
Docosahexaenoic Acid Omega-Hydroxylase
Long-Chain Fatty Acid Omega-Monooxygenase
Phylloquinone Omega-Hydroxylase Cyp4f11
Database Links Reactome: R-HSA-211935
Reactome: R-HSA-211958
Reactome: R-HSA-211979
Reactome: R-HSA-2142691
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Membrane Protein
Microsome Membrane
Alternative Antibody Names Anti-Cytochrome P450 4f11 antibody
Anti-Cypivf11 antibody
Anti-3-Hydroxy Fatty Acids Omega-Hydroxylase Cyp4f11 antibody
Anti-Docosahexaenoic Acid Omega-Hydroxylase antibody
Anti-Long-Chain Fatty Acid Omega-Monooxygenase antibody
Anti-Phylloquinone Omega-Hydroxylase Cyp4f11 antibody
Anti-CYP4F11 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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