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  • 产品名称：Anti-CYP51A1 antibody (210-509) (STJ11105717)

  • 产品型号：STJ11105717
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CYP51A1 antibody (210-509) (STJ11105717)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Lanosterol 14-Alpha Demethylase (210-509) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CYP51A1
Gene ID: 1595
Uniprot ID: CP51A_HUMAN
Immunogen Region: 210-509
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 210-509 of CYP51A1 (NP_000777.1).
Immunogen Sequence: LTASHCLHGKEIRSQLNEKV AQLYADLDGGFSHAAWLLPG WLPLPSFRRRDRAHREIKDI FYKAIQKRRQSQEKIDDILQ TLLDATYKDGRPLTDDEVAG MLIGLLLAGQHTSSTTSAWM GFFLARDKTLQKKCYLEQKT VCGENLPPLTYDQLKDLNLL DRCIKETLRLRPPIMIMMRM ARTPQTVAGYTIPPGHQVCV SPTVNQRLKDSWVERLDFNP DRYLQDNPASGEKFAYVPF
Tissue Specificity Ubiquitously expressed with highest levels in testis, ovary, adrenal, prostate, liver, kidney and lung.
Function Sterol 14alpha-demethylase that plays a critical role in the cholesterol biosynthesis pathway, being cholesterol the major sterol component in mammalian membranes as well as a precursor for bile acid and steroid hormone synthesis. Cytochrome P450 monooxygenase that catalyzes the three-step oxidative removal of the 14alpha-methyl group (C-32) of sterols such as lanosterol (lanosta-8,24-dien-3beta-ol) and 24,25-dihydrolanosterol (DHL) in the form of formate, and converts the sterols to 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol and 4,4-dimethyl-8,14-cholestadien-3beta-ol, respectively, which are intermediates of cholesterol biosynthesis. Can also demethylate substrates not intrinsic to mammals, such as eburicol (24-methylene-24,25-dihydrolanosterol), but at a lower rate than DHL.
Protein Name Lanosterol 14-Alpha Demethylase
Ldm
Cypli
Cytochrome P450 51a1
Cyp51a1
Cytochrome P450-14dm
Cytochrome P45014dm
Cytochrome P450li
Sterol 14-Alpha Demethylase
Database Links Reactome: R-HSA-191273
Reactome: R-HSA-211976
Reactome: R-HSA-2426168
Reactome: R-HSA-9619665
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Membrane Protein
Microsome Membrane
Alternative Antibody Names Anti-Lanosterol 14-Alpha Demethylase antibody
Anti-Ldm antibody
Anti-Cypli antibody
Anti-Cytochrome P450 51a1 antibody
Anti-Cyp51a1 antibody
Anti-Cytochrome P450-14dm antibody
Anti-Cytochrome P45014dm antibody
Anti-Cytochrome P450li antibody
Anti-Sterol 14-Alpha Demethylase antibody
Anti-CYP51A1 antibody
Anti-CYP51 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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