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  • 产品名称：Anti-CYP8B1 antibody (371-420 aa) (STJ92607)

  • 产品型号：STJ92607
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CYP8B1 antibody (371-420 aa) (STJ92607)
详情介绍：
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (371-420 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CYP8B1
Gene ID: 1582
Uniprot ID: CP8B1_HUMAN
Immunogen Region: 371-420 aa
Specificity: CYP8B1 Polyclonal Antibody detects endogenous levels of CYP8B1 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human Cytochrome P450 8B1 at the amino acid range 371-420
Function A cytochrome P450 monooxygenase involved in primary bile acid biosynthesis. Catalyzes the 12alpha-hydroxylation of 7alpha-hydroxy-4-cholesten-3-one, an intermediate metabolite in cholic acid biosynthesis. Controls biliary balance of cholic acid and chenodeoxycholic acid, ultimately regulating the intestinal absorption of dietary lipids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR.NADPH--hemoprotein reductase).
Protein Name 7-Alpha-Hydroxycholest-4-En-3-One 12-Alpha-Hydroxylase
7-Alpha-Hydroxy-4-Cholesten-3-One 12-Alpha-Hydroxylase
Cypviiib1
Cytochrome P450 8b1
Sterol 12-Alpha-Hydroxylase
Database Links Reactome: R-HSA-193368
Reactome: R-HSA-193775
Reactome: R-HSA-193807
Reactome: R-HSA-197264
Reactome: R-HSA-211979
Reactome: R-HSA-211994
Reactome: R-HSA-2162123
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Membrane Protein
Microsome Membrane
Alternative Antibody Names Anti-7-Alpha-Hydroxycholest-4-En-3-One 12-Alpha-Hydroxylase antibody
Anti-7-Alpha-Hydroxy-4-Cholesten-3-One 12-Alpha-Hydroxylase antibody
Anti-Cypviiib1 antibody
Anti-Cytochrome P450 8b1 antibody
Anti-Sterol 12-Alpha-Hydroxylase antibody
Anti-CYP8B1 antibody
Anti-CYP12 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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