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  • 产品名称：Anti-CD272/Btla antibody [PK18.6] (STJA0001340)

  • 产品型号：STJA0001340
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CD272/Btla antibody [PK18.6] (STJA0001340)
详情介绍：
Host: Rat
Applications: FC
Reactivity: Mouse
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Rat monoclonal antibody anti-B-and T-lymphocyte attenuator is suitable for use in Flow Cytometry research applications.
Clonality: Monoclonal
Clone ID: PK18.6
Conjugation: Unconjugated
Isotype: IgG1k
Formulation: 0.2 µm filtered in PBS, pH7.2. Azide Free (AF) /Low Endotoxin (LE) : Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg as determined by LAL gel clotting assay.
Concentration: 0.5 mg/mL
Storage Instruction: Store at 2-8°C. Do not freeze this product.
Gene Symbol: Btla
Gene ID: 208154
Uniprot ID: BTLA_MOUSE
Tissue Specificity Expressed in splenic T- and B-cells as well as lymph node tissues but very weakly in somatic tissues. Also expressed in macrophages, NK cells and dendritic cells. A polymorphic tissue distribution between several strains is seen.
Post Translational Modifications Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11. N-glycosylated.
Function Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells.
Protein Name B- And T-Lymphocyte Attenuator
B- And T-Lymphocyte-Associated Protein
Cd Antigen Cd272
Database Links Reactome: R-MMU-388841
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-B- And T-Lymphocyte Attenuator antibody
Anti-B- And T-Lymphocyte-Associated Protein antibody
Anti-Cd Antigen Cd272 antibody
Anti-Btla antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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