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  • 产品名称：Anti-DCP2 antibody (1-240) (STJ110581)

  • 产品型号：STJ110581
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-DCP2 antibody (1-240) (STJ110581)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-DCP2 (1-240) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DCP2
Gene ID: 167227
Uniprot ID: DCP2_HUMAN
Immunogen Region: 1-240
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human DCP2 (NP_001229306.1).
Immunogen Sequence: METKRVEIPGSVLDDLCSRF ILHIPSEERDNAIRVCFQIE LAHWFYLDFYMQNTPGLPQC GIRDFAKAVFSHCPFLLPQG EDVEKVLDEWKEYKMGVPTY GAIILDETLENVLLVQGYLA KSGWGFPKGKVNKEEAPHDC AAREVFEETGFDIKDYICKD DYIELRINDQLARLYIIPGI PKDTKFNPKTRREIRNIEWF SIEKLPCHRNDMTPKSKLGL APNKFFMAIPFIRPLRDWL
Tissue Specificity Expressed in brain and testis. Not detected in heart (at protein level).
Post Translational Modifications Phosphorylated at ser-249 in a MTOR-dependent manner.
Function Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety. The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2'-O-dimethyladenosine cap.m6A(m)) provides resistance to DCP2-mediated decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts.
Protein Name M7gpppn-Mrna Hydrolase
Nucleoside Diphosphate-Linked Moiety X Motif 20
Nudix Motif 20
Mrna-Decapping Enzyme 2
Hdpc
Database Links Reactome: R-HSA-380994
Reactome: R-HSA-430039
Reactome: R-HSA-450385
Reactome: R-HSA-450513
Reactome: R-HSA-450604
Cellular Localisation Cytoplasm
P-Body
Nucleus
Predominantly Cytoplasmic
In Processing Bodies (Pb)
A Minor Amount Is Nuclear
Alternative Antibody Names Anti-M7gpppn-Mrna Hydrolase antibody
Anti-Nucleoside Diphosphate-Linked Moiety X Motif 20 antibody
Anti-Nudix Motif 20 antibody
Anti-Mrna-Decapping Enzyme 2 antibody
Anti-Hdpc antibody
Anti-DCP2 antibody
Anti-NUDT20 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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