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  • 产品名称：Anti-DCTN1 antibody [3D5-C6-D5] (STJ99032)

  • 产品型号：STJ99032
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-DCTN1 antibody [3D5-C6-D5] (STJ99032)
详情介绍：
Host: Mouse
Applications: WB/IP
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Dynactin subunit 1 is suitable for use in Western Blot and Immunoprecipitation research applications.
Clonality: Monoclonal
Clone ID: 3D5-C6-D5
Conjugation: Unconjugated
Isotype: IgG2b
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DCTN1
Gene ID: 1639
Uniprot ID: DCTN1_HUMAN
Specificity: This antibody detects endogenous levels of Dynactin 1 (N-terminus) , and does not cross-react with related proteins.
Immunogen: Purified recombinant Dynactin 1 protein fragments expressed in E.coli
Post Translational Modifications Ubiquitinated by a SCF complex containing FBXL5, leading to its degradation by the proteasome. Phosphorylation by SLK at Thr-145, Thr-146 and Thr-147 targets DCTN1 to the centrosome. It is uncertain if SLK phosphorylates all three threonines or one or two of them. PLK1-mediated phosphorylation at Ser-179 is essential for its localization in the nuclear envelope, promotes its dissociation from microtubules during early mitosis and positively regulates nuclear envelope breakdown during prophase.
Function Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule. Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon. Plays a role in metaphase spindle orientation. Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole. Plays a role in primary cilia formation.
Protein Name Dynactin Subunit 1
150 Kda Dynein-Associated Polypeptide
Dap-150
Dp-150
P135
P150-Glued
Database Links Reactome: R-HSA-2132295
Reactome: R-HSA-2565942 Q14203-2
Reactome: R-HSA-3371497
Reactome: R-HSA-380259 Q14203-2
Reactome: R-HSA-380270 Q14203-2
Reactome: R-HSA-380284 Q14203-2
Reactome: R-HSA-380320 Q14203-2
Reactome: R-HSA-381038
Reactome: R-HSA-5620912 Q14203-2
Reactome: R-HSA-6807878
Reactome: R-HSA-6811436
Reactome: R-HSA-8854518 Q14203-2
Reactome: R-HSA-9725370
Cellular Localisation Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Centriole
Spindle
Nucleus Envelope
Cell Cortex
Localizes To Microtubule Plus Ends
Localizes Preferentially To The Ends Of Tyrosinated Microtubules
Localization At Centrosome Is Regulated By Slk-Dependent Phosphorylation
Localizes To Centrosome In A Parkda-Dependent Manner
Localizes To The Subdistal Appendage Region Of The Centriole In A Kif3a-Dependent Manner
Plk1-Mediated Phosphorylation At Ser-179 Is Essential For Its Localization In The Nuclear Envelope
Alternative Antibody Names Anti-Dynactin Subunit 1 antibody
Anti-150 Kda Dynein-Associated Polypeptide antibody
Anti-Dap-150 antibody
Anti-Dp-150 antibody
Anti-P135 antibody
Anti-P150-Glued antibody
Anti-DCTN1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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