产品详情
查看大图

  • 产品名称：Anti-CD274 antibody (19-239) (STJ11103333)

  • 产品型号：STJ11103333
  • 产品厂商：ST john's laboratory
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Anti-CD274 antibody (19-239) (STJ11103333)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CD274 (19-239) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:100-1:500
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Cd274
Gene ID: 60533
Uniprot ID: PD1L1_MOUSE
Immunogen Region: 19-239
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 19-239 of mouse CD274 (NP_068693.1).
Immunogen Sequence: FTITAPKDLYVVEYGSNVTM ECRFPVERELDLLALVVYWE KEDEQVIQFVAGEEDLKPQH SNFRGRASLPKDQLLKGNAA LQITDVKLQDAGVYCCIISY GGADYKRITLKVNAPYRKIN QRISVDPATSEHELICQAEG YPEAEVIWTNSDHQPVSGKR SVTTSRTEGMLLNVTSSLRV NATANDVFYCTFWRSQPGQN HTAELIIPELPATHPPQNRT H
Tissue Specificity Highly expressed in the heart, thymus, skeletal muscle, and lung. Weakly expressed in the kidney, spleen, thyroid, and liver. Expressed on activated dendritic cells, B-cells and macrophages. Expressed in numerous tumor cells lines of lymphoid origin.
Post Translational Modifications Ubiquitinated.STUB1 likely mediates polyubiquitination of PD-L1/CD274 triggering its degradation. Ubiquitinated by MARCHF8.leading to degradation.
Function Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival. The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function. The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy.
Protein Name Programmed Cell Death 1 Ligand 1
Pd-L1
Pdcd1 Ligand 1
Programmed Death Ligand 1
B7 Homolog 1
B7-H1
Cd Antigen Cd274
Database Links Reactome: R-MMU-389948
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Early Endosome Membrane
Recycling Endosome Membrane
Alternative Antibody Names Anti-Programmed Cell Death 1 Ligand 1 antibody
Anti-Pd-L1 antibody
Anti-Pdcd1 Ligand 1 antibody
Anti-Programmed Death Ligand 1 antibody
Anti-B7 Homolog 1 antibody
Anti-B7-H1 antibody
Anti-Cd Antigen Cd274 antibody
Anti-Cd274 antibody
Anti-B7h1 antibody
Anti-Pdcd1l1 antibody
Anti-Pdcd1lg1 antibody
Anti-Pdl1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
姓名：
电话：
您的需求：
 

沪公网安备 31011002002624号