产品详情
简单介绍:
Anti-CD274/PD-L1 antibody (C-Term) (STJ70646)
详情介绍:
Host: | Goat |
Applications: | Pep-ELISA/WB/IF/FC |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Goat polyclonal antibody anti-CD274/PD-L1 (C-Term) is suitable for use in ELISA, Western Blot, Immunofluorescence and Flow Cytometry research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
Concentration: | 0.5 mg/mL |
Dilution Range: | IF-Strong expression of the protein seen in th membrane and cytoplasm of U2OS and A431 cells. 10µg/ml ELISA-antibody detection limit dilution 1:128000. |
Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Gene Symbol: | CD274 |
Gene ID: | 29126 |
Uniprot ID: | PD1L1_HUMAN |
Immunogen Region: | C-Term |
Accession Number: | NP_054862.1; NP_001254635.1 |
Specificity: | This antibody is expected to recognize reported isoforms a and b (NP_054862.1; NP_001254635.1) only. |
Immunogen Sequence: | CKKQSDTHLEET |
Post Translational Modifications | Ubiquitinated.STUB1 likely mediates polyubiquitination of PD-L1/CD274 triggering its degradation. Ubiquitinated by MARCHF8.leading to degradation. |
Function | Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). Can also act as a transcription coactivator: in response to hypoxia, translocates into the nucleus via its interaction with phosphorylated STAT3 and promotes transcription of GSDMC, leading to pyroptosis. The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival. The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function. The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy. |
Protein Name | Programmed Cell Death 1 Ligand 1 Pd-L1 Pdcd1 Ligand 1 Programmed Death Ligand 1 Hpd-L1 B7 Homolog 1 B7-H1 Cd Antigen Cd274 |
Database Links | Reactome: R-HSA-389948 Reactome: R-HSA-9701898 |
Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Early Endosome Membrane Recycling Endosome Membrane Nucleus Associates With Cmtm6 At Recycling Endosomes Where It Is Protected From Being Targeted For Lysosomal Degradation Translocates To The Nucleus In Response To Hypoxia Via Its Interaction With Phosphorylated Stat3 Isoform 1: Cell Membrane Isoform 2: Endomembrane System Isoform 4: Secreted |
Alternative Antibody Names | Anti-Programmed Cell Death 1 Ligand 1 antibody Anti-Pd-L1 antibody Anti-Pdcd1 Ligand 1 antibody Anti-Programmed Death Ligand 1 antibody Anti-Hpd-L1 antibody Anti-B7 Homolog 1 antibody Anti-B7-H1 antibody Anti-Cd Antigen Cd274 antibody Anti-CD274 antibody Anti-B7H1 antibody Anti-PDCD1L1 antibody Anti-PDCD1LG1 antibody Anti-PDL1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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