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  • 产品名称：Mouse ERa (Estrogen Receptor Alpha) Sandwich ELISA Kit Ready-To-Use (STJE0015062)

  • 产品型号：STJE0015062
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Mouse ERa (Estrogen Receptor Alpha) Sandwich ELISA Kit Ready-To-Use (STJE0015062)
详情介绍：
Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.146ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This ERa Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Esr1
Gene ID: 13982
Uniprot ID: ESR1_MOUSE
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity
Post Translational Modifications Phosphorylated by cyclin A/CDK2 and CK1. Phosphorylation probably enhances transcriptional activity. Dephosphorylation at Ser-122 by PPP5C inhibits its transactivation activity. Phosphorylated by LMTK3 (in vitro). Ubiquitinated. Deubiquitinated by OTUB1. Palmitoylated at Cys-451 by ZDHHC7 and ZDHHC21. This modification is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation, but not for signaling mediated by the nuclear hormone receptor. Ubiquitinated.regulated by LATS1 via DCAF1 it leads to ESR1 proteasomal degradation. Deubiquitinated by OTUB1. Dimethylated by PRMT1 at Arg-264. The methylation may favor cytoplasmic localization. Demethylated by JMJD6 at Arg-264.
Function Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements.the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3.
Protein Name Estrogen Receptor
Er
Er-Alpha
Estradiol Receptor
Nuclear Receptor Subfamily 3 Group A Member 1
Database Links Reactome: R-MMU-1251985
Reactome: -MMU-1257604
Reactome: -MMU-383280
Reactome: -MMU-4090294
Reactome: -MMU-5689896
Reactome: -MMU-6811558
Reactome: -MMU-8866910
Reactome: -MMU-8931987
Reactome: -MMU-8939211
Reactome: -MMU-9009391
Reactome: -MMU-9018519
Cellular Localisation Nucleus
Cytoplasm
Golgi Apparatus
Cell Membrane
Colocalizes With Zdhhc7 And Zdhhc21 In The Golgi Apparatus Where Most Probably Palmitoylation Occurs
Associated With The Plasma Membrane When Palmitoylated
Alternative ELISA Names Estrogen Receptor ELISA kit
Er ELISA kit
Er-Alpha ELISA kit
Estradiol Receptor ELISA kit
Nuclear Receptor Subfamily 3 Group A Member 1 ELISA kit
Esr1 ELISA kit
Esr ELISA kit
Estr ELISA kit
Estra ELISA kit
Nr3a1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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