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  • 产品名称：Anti-DDX20 antibody (25-280) (STJ28380)

  • 产品型号：STJ28380
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-DDX20 antibody (25-280) (STJ28380)
详情介绍：
Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-DDX20 (25-280) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IF/ICC 1:10-1:100
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DDX20
Gene ID: 11218
Uniprot ID: DDX20_HUMAN
Immunogen Region: 25-280
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 25-280 of human DDX20 (NP_009135.4).
Immunogen Sequence: VQVPAPEPTPGPVRILRTAQ DLSSPRTRTGDVLLAEPADF ESLLLSRPVLEGLRAAGFER PSPVQLKAIPLGRCGLDLIV QAKSGTGKTCVFSTIALDSL VLENLSTQILILAPTREIAV QIHSVITAIGIKMEGLECHV FIGGTPLSQDKTRLKKCHIA VGSPGRIKQLIELDYLNPGS IRLFILDEADKLLEEGSFQE QINWIYSSLPASKQMLAVSA TYPEFLANALTKYMRDPTF
Tissue Specificity Ubiquitous.
Function The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs).
Protein Name Probable Atp-Dependent Rna Helicase Ddx20
Component Of Gems 3
Dead Box Protein 20
Dead Box Protein Dp 103
Gemin-3
Database Links Reactome: R-HSA-191859
Reactome: R-HSA-9754678
Cellular Localisation Cytoplasm
Nucleus
Gem
Localized In Subnuclear Structures Next To Coiled Bodies
Called Gemini Of Cajal Bodies (Gems)
Alternative Antibody Names Anti-Probable Atp-Dependent Rna Helicase Ddx20 antibody
Anti-Component Of Gems 3 antibody
Anti-Dead Box Protein 20 antibody
Anti-Dead Box Protein Dp 103 antibody
Anti-Gemin-3 antibody
Anti-DDX20 antibody
Anti-DP103 antibody
Anti-GEMIN3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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