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  • 产品名称：Anti-DEF6 antibody (STJA0009595)

  • 产品型号：STJA0009595
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-DEF6 antibody (STJA0009595)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Differentially expressed in FDCP 6 homolog is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DEF6
Gene ID: 50619
Uniprot ID: DEFI6_HUMAN
Specificity: This antibody detects endogenous levels of DEF6 at Human, Mouse
Immunogen: Synthesized peptide derived from human DEF6
Post Translational Modifications Tyrosine-phosphorylated by tyrosine-protein kinase LCK in response to T-cell activation.
Function Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Involved in immune homeostasis by ensuring proper trafficking and availability of T-cell regulator CTLA-4 at T-cell surface. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling.
Protein Name Differentially Expressed In Fdcp 6 Homolog
Def-6
Irf4-Binding Protein
Database Links Reactome: R-HSA-8980692
Reactome: R-HSA-9013148
Reactome: R-HSA-9013149
Reactome: R-HSA-9013404
Cellular Localisation Cytoplasm
Cell Membrane
Nucleus
Cytoskeleton
Perinuclear Region
Cell Projection
Filopodium
Recruited To The Plasma Membrane Upon Binding Phosphatidylinositol 3
4
5-Trisphosphate
Binds To Actin Filaments
Alternative Antibody Names Anti-Differentially Expressed In Fdcp 6 Homolog antibody
Anti-Def-6 antibody
Anti-Irf4-Binding Protein antibody
Anti-DEF6 antibody
Anti-IBP antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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