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  • 产品名称：Mouse FUS (Fusion) Sandwich ELISA Kit (STJE0009006)

  • 产品型号：STJE0009006
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Mouse FUS (Fusion) Sandwich ELISA Kit (STJE0009006)
详情介绍：
Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.042ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This FUS Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Fus
Gene ID: 233908
Uniprot ID: FUS_MOUSE
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity
Post Translational Modifications Phosphorylated in its N-terminal serine residues upon induced DNA damage. ATM and DNA-PK are able to phosphorylate FUS N-terminal region.
Function DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response. Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing. Binds also its own pre-mRNA and autoregulates its expression.this autoregulation mechanism is mediated by non-sense-mediated decay. Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair. In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis.
Protein Name Rna-Binding Protein Fus
Protein Pigpen
Database Links Reactome: R-MMU-72163
Reactome: -MMU-72203
Cellular Localisation Nucleus
Displays A Punctate Pattern Inside The Nucleus And Is Excluded From Nucleoli
Alternative ELISA Names Rna-Binding Protein Fus ELISA kit
Protein Pigpen ELISA kit
Fus ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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