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  • 产品名称：Anti-DENND1B antibody (325-375 aa) (STJ194999)

  • 产品型号：STJ194999
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-DENND1B antibody (325-375 aa) (STJ194999)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-DENN domain-containing protein 1B (325-375 aa) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DENND1B
Gene ID: 163486
Uniprot ID: DEN1B_HUMAN
Immunogen Region: 325-375 aa
Specificity: This antibody detects endogenous levels of DEN1B at Human/Mouse
Immunogen: Synthesized peptide derived from the human DEN1B at the amino acid range 325-375
Post Translational Modifications Phosphorylated on serine and/or threonine, possibly regulating the guanine nucleotide exchange factor (GEF) activity.
Function Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells. Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Plays a role in clathrin-mediated endocytosis. Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity. Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells.
Protein Name Denn Domain-Containing Protein 1b
Connecdenn 2
Protein Fam31b
Database Links Reactome: R-HSA-8876198
Cellular Localisation Cytoplasm
Cytosol
Cytoplasmic Vesicle
Clathrin-Coated Vesicle
Alternative Antibody Names Anti-Denn Domain-Containing Protein 1b antibody
Anti-Connecdenn 2 antibody
Anti-Protein Fam31b antibody
Anti-DENND1B antibody
Anti-C1orf218 antibody
Anti-FAM31B antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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