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  • 产品名称：Anti-DGKD antibody (960-1140) (STJ117309)

  • 产品型号：STJ117309
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-DGKD antibody (960-1140) (STJ117309)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-DGKD (960-1140) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DGKD
Gene ID: 8527
Uniprot ID: DGKD_HUMAN
Immunogen Region: 960-1140
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 960-1140 of human DGKD (NP_690618.2).
Immunogen Sequence: LPRPPSCSLHPEMLSEEEAT QMDQFGQAAGVLIHSIREIA QSHRDMEQELAHAVNASSKS MDRVYGKPRTTEGLNCSFVL EMVNNFRALRSETELLLSGK MALQLDPPQKEQLGSALAEM DRQLRRLADTPWLCQSAEPG DEESVMLDLAKRSRSGKFRL VTKFKKEKNNKNKEAHSSLG A
Tissue Specificity Isoform 2: Widely expressed. Isoform 1: Only detected in ovary, and to a lesser extent in spleen.
Post Translational Modifications Isoform 1: Phosphorylated. Phosphorylation by PKC induced by phorbol esters prevents homooligomerization and promotes association with membranes.
Function Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development. May also regulate clathrin-dependent endocytosis.
Protein Name Diacylglycerol Kinase Delta
Dag Kinase Delta
130 Kda Diacylglycerol Kinase
Diglyceride Kinase Delta
Dgk-Delta
Database Links Reactome: R-HSA-114508
Cellular Localisation Membrane
Clathrin-Coated Pit
Cytoplasm
Isoform 1: Cell Membrane
Peripheral Membrane Protein
Isoform 1 Translocation From Cytoplasm To The Plasma Membrane Is Induced By Phorbol Esters
Phorbol Esters Induce The Conversion Into The Monomeric Form Which Can Translocate To The Plasma Membrane
Alternative Antibody Names Anti-Diacylglycerol Kinase Delta antibody
Anti-Dag Kinase Delta antibody
Anti-130 Kda Diacylglycerol Kinase antibody
Anti-Diglyceride Kinase Delta antibody
Anti-Dgk-Delta antibody
Anti-DGKD antibody
Anti-KIAA0145 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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