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  • 产品名称：Mouse GHR (Growth Hormone Receptor) Sandwich ELISA Kit Ready-To-Use (STJE0015535)

  • 产品型号：STJE0015535
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Mouse GHR (Growth Hormone Receptor) Sandwich ELISA Kit Ready-To-Use (STJE0015535)
详情介绍：
Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.116ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This GHR Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Ghr
Gene ID: 14600
Uniprot ID: GHR_MOUSE
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Expressed in all tissues tested including, liver, heart, adipose tissue, mammary gland, testes, ovary, brain, kidney and muscle. Highest levels in liver.
Post Translational Modifications On GH binding, phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2. On ligand binding, ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for GHR internalization.
Function Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
Protein Name Growth Hormone Receptor
Gh Receptor
Somatotropin Receptor Cleaved Into - Growth Hormone-Binding Protein
Gh-Binding Protein
Ghbp
Serum-Binding Protein
Database Links Reactome: R-MMU-1170546
Reactome: -MMU-982772
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
On Growth Hormone Binding
Ghr Is Ubiquitinated
Internalized
Down-Regulated And Transported Into A Degradative Or Non-Degradative Pathway
Isoform 2: Secreted
Growth Hormone-Binding Protein: Secreted
Complexed To A Substantial Fraction Of Circulating Gh
Alternative ELISA Names Growth Hormone Receptor ELISA kit
Gh Receptor ELISA kit
Somatotropin Receptor Cleaved Into - Growth Hormone-Binding Protein ELISA kit
Gh-Binding Protein ELISA kit
Ghbp ELISA kit
Serum-Binding Protein ELISA kit
Ghr ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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