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  • 产品名称：Anti-DHRS4 antibody (1-278) (STJ112323)

  • 产品型号：STJ112323
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-DHRS4 antibody (1-278) (STJ112323)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-DHRS4 (1-278) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:1000-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DHRS4
Gene ID: 10901
Uniprot ID: DHRS4_HUMAN
Immunogen Region: 1-278
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-278 of human DHRS4 (NP_066284.2).
Immunogen Sequence: MHKAGLLGLCARAWNSVRMA SSGMTRRDPLANKVALVTAS TDGIGFAIARRLAQDGAHVV VSSRKQQNVDQAVATLQGEG LSVTGTVCHVGKAEDRERLV ATAVKLHGGIDILVSNAAVN PFFGSIMDVTEEVWDKTLDI NVKAPALMTKAVVPEMEKRG GGSVVIVSSIAAFSPSPGFS PYNVSKTALLGLTKTLAIEL APRNIRVNCLAPGLIKTSFS RMLWMDKEKEESMKETLRI
Tissue Specificity Isoform 1: Predominantly expressed in normal cervix (at protein level). Isoform 4: Expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level). Isoform 5: Expressed in a few neoplastic cervical tissues. Isoform 6: Expressed in a few neoplastic cervical tissues. Isoform 8: High expression in liver.
Function NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including ketosteroids, alpha-dicarbonyl compounds, aldehydes, aromatic ketones and quinones. Reduces 3-ketosteroids and benzil into 3beta-hydroxysteroids and R-benzoin, respectively, in contrast to the stereoselectivity of non-primate DHRS4s which produce 3alpha-hydroxysteroids and S-benzoin. Diplays low activity toward all-trans-retinal and no activity toward 9-cis-retinal as compared to non-primate mammals. In the reverse reaction, catalyze the NAD-dependent oxidation of 3beta-hydroxysteroids and alcohol, but with much lower efficiency. Involved in the metabolism of 3beta-hydroxysteroids, isatin and xenobiotic carbonyl compounds. Isoform 7: No detected catalytic activity in vitro, possibly due to the lack of catalytic site. Isoform 8: NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including ketosteroids, alpha-dicarbonyl compounds, aldehydes, aromatic ketones and quinones. Involved in the metabolism of 3beta-hydroxysteroids, isatin and xenobiotic carbonyl compounds. Has a higher catalytic activity for xenobiotic alpha-dicarbonyl compounds, sucha as benzil, than isoform 1 and is involved in benzil detoxification.
Protein Name Dehydrogenase/Reductase Sdr Family Member 4
Nadph-Dependent Carbonyl Reductase
Cr
Nadph-Dependent Retinol Dehydrogenase/Reductase
Nrdr
Humnrdr
Peroxisomal Short-Chain Alcohol Dehydrogenase
Pscd
Scad-Srl
Short Chain Dehydrogenase/Reductase Family 25c Member 2
Protein Sdr25c2
Short-Chain Dehydrogenase/Reductase Family Member 4
Database Links Reactome: R-HSA-5365859
Reactome: R-HSA-9033241
Cellular Localisation Isoform 1: Peroxisome
Isoform 4 Is Not Peroxisomal
Isoform 7: Nucleus
Alternative Antibody Names Anti-Dehydrogenase/Reductase Sdr Family Member 4 antibody
Anti-Nadph-Dependent Carbonyl Reductase antibody
Anti-Cr antibody
Anti-Nadph-Dependent Retinol Dehydrogenase/Reductase antibody
Anti-Nrdr antibody
Anti-Humnrdr antibody
Anti-Peroxisomal Short-Chain Alcohol Dehydrogenase antibody
Anti-Pscd antibody
Anti-Scad-Srl antibody
Anti-Short Chain Dehydrogenase/Reductase Family 25c Member 2 antibody
Anti-Protein Sdr25c2 antibody
Anti-Short-Chain Dehydrogenase/Reductase Family Member 4 antibody
Anti-DHRS4 antibody
Anti-SDR25C2 antibody
Anti-UNQ851 antibody
Anti-PRO1800 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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