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  • 产品名称：Anti-DHX15 antibody (STJA0007463)

  • 产品型号：STJA0007463
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-DHX15 antibody (STJA0007463)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ATP-dependent RNA helicase DHX15 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DHX15
Gene ID: 1665
Uniprot ID: DHX15_HUMAN
Specificity: This antibody detects endogenous levels of DHX15 at Human, Mouse
Immunogen: Synthesized peptide derived from human DHX15
Function RNA helicase involved in mRNA processing and antiviral innate immunity. Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. Plays a key role in antiviral innate immunity by promoting both MAVS-dependent signaling and NLRP6 inflammasome. Acts as an RNA virus sensor: recognizes and binds viral double stranded RNA (dsRNA) and activates the MAVS-dependent signaling to produce interferon-beta and interferon lambda-3 (IFNL3). Involved in intestinal antiviral innate immunity together with NLRP6: recognizes and binds viral dsRNA and promotes activation of the NLRP6 inflammasome in intestinal epithelial cells to restrict infection by enteric viruses. The NLRP6 inflammasome acts by promoting maturation and secretion of IL18 in the extracellular milieu. Also involved in antibacterial innate immunity by promoting Wnt-induced antimicrobial protein expression in Paneth cells.
Protein Name Atp-Dependent Rna Helicase Dhx15
Atp-Dependent Rna Helicase #46
Deah Box Protein 15
Splicing Factor Prp43
Hprp43
Database Links Reactome: R-HSA-72163
Cellular Localisation Nucleus
Nucleolus
Alternative Antibody Names Anti-Atp-Dependent Rna Helicase Dhx15 antibody
Anti-Atp-Dependent Rna Helicase #46 antibody
Anti-Deah Box Protein 15 antibody
Anti-Splicing Factor Prp43 antibody
Anti-Hprp43 antibody
Anti-DHX15 antibody
Anti-DBP1 antibody
Anti-DDX15 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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