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  • 产品名称：Anti-DHX58 antibody (389-678) (STJ110556)

  • 产品型号：STJ110556
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-DHX58 antibody (389-678) (STJ110556)
详情介绍：
Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-DHX58 (389-678) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DHX58
Gene ID: 79132
Uniprot ID: DHX58_HUMAN
Immunogen Region: 389-678
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 389-678 of human DHX58 (NP_077024.2).
Immunogen Sequence: QQQGLQTVDIRAQLLIGAGN SSQSTHMTQRDQQEVIQKFQ DGTLNLLVATSVAEEGLDIP HCNVVVRYGLLTNEISMVQA RGRARADQSVYAFVATEGSR ELKRELINEALETLMEQAVA AVQKMDQAEYQAKIRDLQQA ALTKRAAQAAQRENQRQQFP VEHVQLLCINCMVAVGHGSD LRKVEGTHHVNVNPNFSNYY NVSRDPVVINKVFKDWKPGG VISCRNCGEVWGLQMIYKS
Tissue Specificity Expressed in testis, nerve and spleen. Also expressed in the brain.
Function Acts as a regulator of RIGI and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to RIGI and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on RIG-I signaling may involve the following mechanisms: competition with RIGI for binding to the viral RNA, binding to RIGI and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by RIGI and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses and coronavirus SARS-CoV-2, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.
Protein Name Atp-Dependent Rna Helicase Dhx58
Atp-Dependent Helicase Lgp2
Protein D11lgp2 Homolog
Rig-I-Like Receptor 3
Rlr-3
Rig-I-Like Receptor Lgp2
Rlr
Database Links Reactome: R-HSA-168928
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Atp-Dependent Rna Helicase Dhx58 antibody
Anti-Atp-Dependent Helicase Lgp2 antibody
Anti-Protein D11lgp2 Homolog antibody
Anti-Rig-I-Like Receptor 3 antibody
Anti-Rlr-3 antibody
Anti-Rig-I-Like Receptor Lgp2 antibody
Anti-Rlr antibody
Anti-DHX58 antibody
Anti-D11LGP2E antibody
Anti-LGP2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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