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  • 产品名称：Mouse GRIA2 (Glutamate Receptor, Ionotropic, AMPA 2) Sandwich ELISA Kit (STJE0009294)

  • 产品型号：STJE0009294
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Mouse GRIA2 (Glutamate Receptor, Ionotropic, AMPA 2) Sandwich ELISA Kit (STJE0009294)
详情介绍：
Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.058ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This GRIA2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Gria2Uniprot ID=GRIA2_MOUSE"
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Detected in brain cortex, hippocampus and cerebellum (at protein level). Detected in hippocampus.
Post Translational Modifications Palmitoylated. Depalmitoylated upon glutamate stimulation. ZDHHC3/GODZ specifically palmitoylates Cys-610, which leads to Golgi retention and decreased cell surface expression. In contrast, Cys-836 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis. N-glycosylated. Phosphorylation at Tyr-876 is required forc interaction with IQSEC1 and ARF6 activation. Ubiquitinated by RNF167, leading to its degradation.
Function Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting.
Protein Name Glutamate Receptor 2
Glur-2
Ampa-Selective Glutamate Receptor 2
Glur-B
Glur-K2
Glutamate Receptor Ionotropic - Ampa 2
Glua2
Database Links
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Endoplasmic Reticulum Membrane
Postsynaptic Cell Membrane
Postsynaptic Density Membrane
Interaction With Cacng2
Cnih2 And Cnih3 Promotes Cell Surface Expression
Displays A Somatodendritic Localization And Is Excluded From Axons In Neurons
Alternative ELISA Names Glutamate Receptor 2 ELISA kit
Glur-2 ELISA kit
Ampa-Selective Glutamate Receptor 2 ELISA kit
Glur-B ELISA kit
Glur-K2 ELISA kit
Glutamate Receptor Ionotropic - Ampa 2 ELISA kit
Glua2 ELISA kit
Gria2 ELISA kit
Glur2 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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