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  • 产品名称：Anti-DLG4 antibody (1-100) (STJ110199)

  • 产品型号：STJ110199
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-DLG4 antibody (1-100) (STJ110199)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-DLG4 (1-100) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DLG4
Gene ID: 1742
Uniprot ID: DLG4_HUMAN
Immunogen Region: 1-100
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PSD95 (NP_001308004.1).
Immunogen Sequence: MDCLCIVTTKKYRYQDEDTP PLEHSPAHLPNQANSPPVIV NTDTLEAPGYELQVNGTEGE MEYEEITLERGNSGLGFSIA GGTDNPHIGDDPSIFITKII
Tissue Specificity Brain.
Post Translational Modifications Palmitoylated. Palmitoylation is required for targeting to postsynaptic density, plasma membrane and synapses. Palmitoylation by ZDHHC2 occurs when the synaptic activity decreases and induces DLG4 synaptic clustering. Palmitoylation by ZDHHC15 regulates trafficking to the postsynaptic density and function in synaptogenesis. Palmitoylation may play a role in glutamate receptor GRIA1 synapse clustering. Depalmitoylated by ABHD17A and ABHD17B and to a lesser extent by ABHD17C, ABHD12, ABHD13, LYPLA1 and LYPLA2. Undergoes rapid synaptic palmitoylation/depalmitoylation cycles during neuronal development which slow down in mature neurons. Ubiquitinated by MDM2 in response to NMDA receptor activation, leading to proteasome-mediated degradation of DLG4 which is required for AMPA receptor endocytosis.
Function Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression. Under basal conditions, cooperates with FYN to stabilize palmitoyltransferase ZDHHC5 at the synaptic membrane through FYN-mediated phosphorylation of ZDHHC5 and its subsequent inhibition of association with endocytic proteins.
Protein Name Disks Large Homolog 4
Postsynaptic Density Protein 95
Psd-95
Synapse-Associated Protein 90
Sap-90
Sap90
Database Links Reactome: R-HSA-1236394
Reactome: R-HSA-399719
Reactome: R-HSA-438066
Reactome: R-HSA-442982
Reactome: R-HSA-447038
Reactome: R-HSA-451308
Reactome: R-HSA-5625900
Reactome: R-HSA-5673001
Reactome: R-HSA-5682910
Reactome: R-HSA-6794361
Reactome: R-HSA-8849932
Reactome: R-HSA-9609736
Reactome: R-HSA-9617324
Reactome: R-HSA-9620244
Cellular Localisation Cell Membrane
Lipid-Anchor
Cytoplasmic Side
Postsynaptic Density
Synapse
Cytoplasm
Cell Projection
Axon
Dendritic Spine
Dendrite
Presynapse
High Levels In Postsynaptic Density Of Neurons In The Forebrain
Also In Presynaptic Region Of Inhibitory Synapses Formed By Cerebellar Basket Cells On Axon Hillocks Of Purkinje Cells
Suppression Of Neuronal Activity Induces Synaptic Accumulation And Clustering Of Dlg4
Alternative Antibody Names Anti-Disks Large Homolog 4 antibody
Anti-Postsynaptic Density Protein 95 antibody
Anti-Psd-95 antibody
Anti-Synapse-Associated Protein 90 antibody
Anti-Sap-90 antibody
Anti-Sap90 antibody
Anti-DLG4 antibody
Anti-PSD95 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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