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  • 产品名称：Anti-DLG5 antibody (STJA0008048)

  • 产品型号：STJA0008048
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-DLG5 antibody (STJA0008048)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Disks large homolog 5 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DLG5
Gene ID: 9231
Uniprot ID: DLG5_HUMAN
Specificity: This antibody detects endogenous levels of DLG5 at Human
Immunogen: Synthesized peptide derived from human DLG5
Function Acts as a regulator of the Hippo signaling pathway. Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1. Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion. Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons.regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation.
Protein Name Disks Large Homolog 5
Discs Large Protein P-Dlg
Placenta And Prostate Dlg
Database Links Reactome: R-HSA-9013420
Reactome: R-HSA-9013424
Reactome: R-HSA-9696264
Reactome: R-HSA-9696270
Reactome: R-HSA-9696273
Cellular Localisation Cell Junction
Cell Membrane
Peripheral Membrane Protein
Postsynaptic Density
Cytoplasm
Cytoskeleton
Cilium Basal Body
Localized At Sites Of Cell-Cell Contact
Alternative Antibody Names Anti-Disks Large Homolog 5 antibody
Anti-Discs Large Protein P-Dlg antibody
Anti-Placenta And Prostate Dlg antibody
Anti-DLG5 antibody
Anti-KIAA0583 antibody
Anti-PDLG antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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