产品详情
简单介绍:
Anti-DMPK antibody (350-590) (STJ112472)
详情介绍:
Host: | Rabbit |
Applications: | WB |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-DMPK (350-590) is suitable for use in Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:2000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | DMPK |
Gene ID: | 1760 |
Uniprot ID: | DMPK_HUMAN |
Immunogen Region: | 350-590 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 350-590 of human DMPK (NP_004400.4). |
Immunogen Sequence: | SVPPFTPDFEGATDTCNFDL VEDGLTAMVSGGGETLSDIR EGAPLGVHLPFVGYSYSCMA LRDSEVPGPTPMELEAEQLL EPHVQAPSLEPSVSPQDETA EVAVPAAVPAAEAEAEVTLR ELQEALEEEVLTRQSLSREM EAIRTDNQNFASQLREAEAR NRDLEAHVRQLQERMELLQA EGATAVTGVPSPRATDPPSH LDGPPAVAVGQCPLVGPGPM HRRHLLLPARVPRPGLSEA |
Tissue Specificity | Most isoforms are expressed in many tissues including heart, skeletal muscle, liver and brain, except for isoform 2 which is only found in the heart and skeletal muscle, and isoform 14 which is only found in the brain, with high levels in the striatum, cerebellar cortex and pons. |
Post Translational Modifications | Phosphorylated. Autophosphorylates. Phosphorylation by RAF1 may result in activation of DMPK. Proteolytic processing of the C-terminus may remove the transmembrane domain and release the kinase from membranes stimulating its activity. |
Function | Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity. |
Protein Name | Myotonin-Protein Kinase Mt-Pk Dm-Kinase Dmk Dm1 Protein Kinase Dmpk Myotonic Dystrophy Protein Kinase |
Database Links | Reactome: R-HSA-5578775 |
Cellular Localisation | Endoplasmic Reticulum Membrane Single-Pass Type Iv Membrane Protein Cytoplasmic Side Nucleus Outer Membrane Mitochondrion Outer Membrane Sarcoplasmic Reticulum Membrane Cell Membrane Cytoplasm Cytosol Localizes To Sarcoplasmic Reticulum Membranes Of Cardiomyocytes Isoform 1: Mitochondrion Membrane Isoform 3: Mitochondrion Membrane |
Alternative Antibody Names | Anti-Myotonin-Protein Kinase antibody Anti-Mt-Pk antibody Anti-Dm-Kinase antibody Anti-Dmk antibody Anti-Dm1 Protein Kinase antibody Anti-Dmpk antibody Anti-Myotonic Dystrophy Protein Kinase antibody Anti-DMPK antibody Anti-DM1PK antibody Anti-MDPK antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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