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  • 产品名称：Anti-DMPK antibody (350-590) (STJ112472)

  • 产品型号：STJ112472
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-DMPK antibody (350-590) (STJ112472)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-DMPK (350-590) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DMPK
Gene ID: 1760
Uniprot ID: DMPK_HUMAN
Immunogen Region: 350-590
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 350-590 of human DMPK (NP_004400.4).
Immunogen Sequence: SVPPFTPDFEGATDTCNFDL VEDGLTAMVSGGGETLSDIR EGAPLGVHLPFVGYSYSCMA LRDSEVPGPTPMELEAEQLL EPHVQAPSLEPSVSPQDETA EVAVPAAVPAAEAEAEVTLR ELQEALEEEVLTRQSLSREM EAIRTDNQNFASQLREAEAR NRDLEAHVRQLQERMELLQA EGATAVTGVPSPRATDPPSH LDGPPAVAVGQCPLVGPGPM HRRHLLLPARVPRPGLSEA
Tissue Specificity Most isoforms are expressed in many tissues including heart, skeletal muscle, liver and brain, except for isoform 2 which is only found in the heart and skeletal muscle, and isoform 14 which is only found in the brain, with high levels in the striatum, cerebellar cortex and pons.
Post Translational Modifications Phosphorylated. Autophosphorylates. Phosphorylation by RAF1 may result in activation of DMPK. Proteolytic processing of the C-terminus may remove the transmembrane domain and release the kinase from membranes stimulating its activity.
Function Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity.
Protein Name Myotonin-Protein Kinase
Mt-Pk
Dm-Kinase
Dmk
Dm1 Protein Kinase
Dmpk
Myotonic Dystrophy Protein Kinase
Database Links Reactome: R-HSA-5578775
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Type Iv Membrane Protein
Cytoplasmic Side
Nucleus Outer Membrane
Mitochondrion Outer Membrane
Sarcoplasmic Reticulum Membrane
Cell Membrane
Cytoplasm
Cytosol
Localizes To Sarcoplasmic Reticulum Membranes Of Cardiomyocytes
Isoform 1: Mitochondrion Membrane
Isoform 3: Mitochondrion Membrane
Alternative Antibody Names Anti-Myotonin-Protein Kinase antibody
Anti-Mt-Pk antibody
Anti-Dm-Kinase antibody
Anti-Dmk antibody
Anti-Dm1 Protein Kinase antibody
Anti-Dmpk antibody
Anti-Myotonic Dystrophy Protein Kinase antibody
Anti-DMPK antibody
Anti-DM1PK antibody
Anti-MDPK antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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