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  • 产品名称：Anti-DNAJC5 antibody (1-198) (STJ112513)

  • 产品型号：STJ112513
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-DNAJC5 antibody (1-198) (STJ112513)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-DNAJC5 (1-198) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:1000-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DNAJC5
Gene ID: 80331
Uniprot ID: DNJC5_HUMAN
Immunogen Region: 1-198
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-198 of human DNAJC5 (NP_079495.1).
Immunogen Sequence: MADQRQRSLSTSGESLYHVL GLDKNATSDDIKKSYRKLAL KYHPDKNPDNPEAADKFKEI NNAHAILTDATKRNIYDKYG SLGLYVAEQFGEENVNTYFV LSSWWAKALFVFCGLLTCCY CCCCLCCCFNCCCGKCKPKA PEGEETEFYVSPEDLEAQLQ SDEREATDTPIVIQPASATE TTQLTADSHPSYHTDGFN
Tissue Specificity Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart.
Post Translational Modifications Ser-10 phosphorylation induces an order-to-disorder transition triggering the interaction with Lys-58. This conformational switch modulates DNAJC5's cellular functions by reducing binding to syntaxin and synaptogamin without altering HSC70 interactions. Palmitoylated. Could be palmitoylated by DHHC3, DHHC7, DHHC15 and DHHC17. Palmitoylation occurs probably in the cysteine-rich domain and regulates DNAJC5 membrane attachment.
Function Acts as a general chaperone in regulated exocytosis. Acts as a co-chaperone for the SNARE protein SNAP-25. Involved in the calcium-mediated control of a late stage of exocytosis. May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings.
Protein Name Dnaj Homolog Subfamily C Member 5
Ceroid-Lipofuscinosis Neuronal Protein 4
Cysteine String Protein
Csp
Database Links Reactome: R-HSA-6798695
Reactome: R-HSA-888590
Reactome: R-HSA-9662360
Cellular Localisation Cytoplasm
Cytosol
Membrane
Lipid-Anchor
Cytoplasmic Vesicle
Secretory Vesicle
Chromaffin Granule Membrane
Melanosome
Cell Membrane
The Association With Membranes Is Regulated By Palmitoylation
Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv
Alternative Antibody Names Anti-Dnaj Homolog Subfamily C Member 5 antibody
Anti-Ceroid-Lipofuscinosis Neuronal Protein 4 antibody
Anti-Cysteine String Protein antibody
Anti-Csp antibody
Anti-DNAJC5 antibody
Anti-CLN4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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