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  • 产品名称：Anti-DOCK3 antibody (STJ11105167)

  • 产品型号：STJ11105167
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-DOCK3 antibody (STJ11105167)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Dedicator Of Cytokinesis Protein 3 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:1000-1:5000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DOCK3
Gene ID: 1795
Uniprot ID: DOCK3_HUMAN
Immunogen: Recombinant protein of human DOCK3.
Tissue Specificity In normal brains, it is localized in the neuropil, and occasionally in the pyramidal cells, while in Alzheimer disease brains, it is associated with neurofibrillary tangles.
Function Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of amyloid-beta APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors.
Protein Name Dedicator Of Cytokinesis Protein 3
Modifier Of Cell Adhesion
Presenilin-Binding Protein
Pbp
Database Links Reactome: R-HSA-9013149
Reactome: R-HSA-9013404
Reactome: R-HSA-9013408
Reactome: R-HSA-9032759
Reactome: R-HSA-983231
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Dedicator Of Cytokinesis Protein 3 antibody
Anti-Modifier Of Cell Adhesion antibody
Anti-Presenilin-Binding Protein antibody
Anti-Pbp antibody
Anti-DOCK3 antibody
Anti-KIAA0299 antibody
Anti-MOCA antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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