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  • 产品名称：Anti-DOCK8 antibody (STJA0007167)

  • 产品型号：STJA0007167
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-DOCK8 antibody (STJA0007167)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Dedicator of cytokinesis protein 8 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DOCK8
Gene ID: 81704
Uniprot ID: DOCK8_HUMAN
Specificity: This antibody detects endogenous levels of DOCK8 at Human, Mouse
Immunogen: Synthesized peptide derived from human DOCK8
Post Translational Modifications In response to chemokine CXCL12/SDF-1-alpha stimulation, phosphorylated by PRKCA/PKC-alpha which promotes DOCK8 dissociation from LRCH1.
Function Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC. Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing.
Protein Name Dedicator Of Cytokinesis Protein 8
Database Links Reactome: R-HSA-9013148
Reactome: R-HSA-9013149
Reactome: R-HSA-9013409
Reactome: R-HSA-983231
Cellular Localisation Cytoplasm
Cell Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Cell Projection
Lamellipodium Membrane
Enriched And Co-Localizes With Gtpase Cdc42 At The Immunological Synapse Formed During T Cell/Antigen Presenting Cell Cognate Interaction
Translocates From The Cytoplasm To The Plasma Membrane In Response To Chemokine Cxcl12/Sdf-1-Alpha Stimulation
Alternative Antibody Names Anti-Dedicator Of Cytokinesis Protein 8 antibody
Anti-DOCK8 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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