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  • 产品名称：Anti-DVL2 antibody (1-240) (STJ116926)

  • 产品型号：STJ116926
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-DVL2 antibody (1-240) (STJ116926)
详情介绍：
Host: Rabbit
Applications: IF
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-DVL2 (1-240) is suitable for use in Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DVL2
Gene ID: 1856
Uniprot ID: DVL2_HUMAN
Immunogen Region: 1-240
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human DVL2 (NP_004413.1).
Immunogen Sequence: MAGSSTGGGGVGETKVIYHL DEEETPYLVKIPVPAERITL GDFKSVLQRPAGAKYFFKSM DQDFGVVKEEISDDNARLPC FNGRVVSWLVSSDNPQPEMA PPVHEPRAELAPPAPPLPPL PPERTSGIGDSRPPSFHPNV SSSHENLEPETETESVVSLR RERPRRRDSSEHGAGGHRTG GPSRLERHLAGYESSSTLMT SELESTSLGDSDEEDTMSRF SSSTEQSSASRLLKRHRRR
Post Translational Modifications Phosphorylated by CSNK1D. WNT3A induces DVL2 phosphorylation by CSNK1E and MARK kinases.
Function Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling.
Protein Name Segment Polarity Protein Dishevelled Homolog Dvl-2
Dishevelled-2
Dsh Homolog 2
Database Links Reactome: R-HSA-201681
Reactome: R-HSA-201688
Reactome: R-HSA-2028269
Reactome: R-HSA-4086400
Reactome: R-HSA-4608870
Reactome: R-HSA-4641258
Reactome: R-HSA-4641262
Reactome: R-HSA-5099900
Reactome: R-HSA-5368598
Reactome: R-HSA-5663220
Reactome: R-HSA-8856825
Reactome: R-HSA-8856828
Reactome: R-HSA-9673324
Cellular Localisation Cell Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Cytoplasm
Cytosol
Cytoplasmic Vesicle
Nucleus
Localizes At The Cell Membrane Upon Interaction With Frizzled Family Members And Promotes Their Internalization
Localizes To Cytoplasmic Puncta
Interaction With Foxk1 And Foxk2 Induces Nuclear Translocation
Alternative Antibody Names Anti-Segment Polarity Protein Dishevelled Homolog Dvl-2 antibody
Anti-Dishevelled-2 antibody
Anti-Dsh Homolog 2 antibody
Anti-DVL2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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