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  • 产品名称：Anti-DYNLL1 antibody (1-50 aa) (STJ196603)

  • 产品型号：STJ196603
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-DYNLL1 antibody (1-50 aa) (STJ196603)
详情介绍：
Host: Rabbit
Applications: IHC/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Dynein light chain 1, cytoplasmic (1-50 aa) is suitable for use in Immunohistochemistry and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC-P 1:50-200
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DYNLL1
Gene ID: 8655
Uniprot ID: DYL1_HUMAN
Immunogen Region: 1-50 aa
Specificity: This antibody detects endogenous levels of DYL1 at Human/Mouse/Rat
Immunogen: Synthesized peptide derived from the human DYL1 at the amino acid range 1-50
Post Translational Modifications Phosphorylation at Ser-88 appears to control the dimer-monomer transition. it is phosphorylated at Ser-88 by PAK1, however, the DYNLL1 dimer is not accessible for PAK1 and the phosphorylation could not be demonstrated in vitro.
Function Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1. Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity. Binds and inhibits the catalytic activity of neuronal nitric oxide synthase/NOS1.
Protein Name Dynein Light Chain 1 - Cytoplasmic
8 Kda Dynein Light Chain
Dlc8
Dynein Light Chain Lc8-Type 1
Protein Inhibitor Of Neuronal Nitric Oxide Synthase
Pin
Database Links Reactome: R-HSA-111446
Reactome: R-HSA-141444
Reactome: R-HSA-1632852
Reactome: R-HSA-2132295
Reactome: R-HSA-2467813
Reactome: R-HSA-2500257
Reactome: R-HSA-2565942
Reactome: R-HSA-3371497
Reactome: R-HSA-380259
Reactome: R-HSA-380270
Reactome: R-HSA-380284
Reactome: R-HSA-380320
Reactome: R-HSA-5620912
Reactome: R-HSA-5620924
Reactome: R-HSA-5663220
Reactome: R-HSA-6798695
Reactome: R-HSA-6807878
Reactome: R-HSA-6811436
Reactome: R-HSA-68877
Reactome: R-HSA-8854518
Reactome: R-HSA-9609690
Reactome: R-HSA-9646399
Reactome: R-HSA-9648025
Cellular Localisation Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Nucleus
Mitochondrion
Upon Induction Of Apoptosis Translocates Together With Bcl2l11 To Mitochondria
Alternative Antibody Names Anti-Dynein Light Chain 1 - Cytoplasmic antibody
Anti-8 Kda Dynein Light Chain antibody
Anti-Dlc8 antibody
Anti-Dynein Light Chain Lc8-Type 1 antibody
Anti-Protein Inhibitor Of Neuronal Nitric Oxide Synthase antibody
Anti-Pin antibody
Anti-DYNLL1 antibody
Anti-DLC1 antibody
Anti-DNCL1 antibody
Anti-DNCLC1 antibody
Anti-HDLC1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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