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  • 产品名称：Anti-DZIP1 antibody (73-123 aa) (STJ194668)

  • 产品型号：STJ194668
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-DZIP1 antibody (73-123 aa) (STJ194668)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Cilium assembly protein DZIP1 (73-123 aa) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DZIP1
Gene ID: 22873
Uniprot ID: DZIP1_HUMAN
Immunogen Region: 73-123 aa
Specificity: This antibody detects endogenous levels of DZIP1 at Human/Mouse
Immunogen: Synthesized peptide derived from the human DZIP1 at the amino acid range 73-123
Post Translational Modifications Phosphorylation at Ser-226 by PLK1 before mitosis prevents interaction with PCM1 and localization to centriolar satellites. Thereby, it negatively regulates the localization of the BBSome to centriolar satellites.
Function Molecular adapter that recruits protein complexes required for cilium assembly and function to the cilium basal body. At the exit of mitosis, localizes to the basal body and ciliary base of the forming primary cilium where it recruits and activates RAB8A to direct vesicle-mediated transport of proteins to the cilium. Also recruits the BBSome, a complex involved in cilium biogenesis, by bridging it to PCM1 at the centriolar satellites of the cilium. It is also required for the recruitment to the cilium basal body of the intraflagellar transport (IFT) machinery as well as the ciliary appendage proteins CEP164 and NINEIN. Functions as a regulator of Hedgehog signaling both through its role in cilium assembly but also probably through its ability to retain GLI3 within the cytoplasm. It is involved in spermatogenesis through its role in organization of the basal body and assembly of the sperm flagellum. Also indirectly involved in heart development through its function in ciliogenesis.
Protein Name Cilium Assembly Protein Dzip1
Daz-Interacting Protein 1/2
Daz-Interacting Zinc Finger Protein 1
Database Links Reactome: R-HSA-5632684
Cellular Localisation Cytoplasm
Cytoskeleton
Cilium Basal Body
Microtubule Organizing Center
Centrosome
Centriolar Satellite
Centriole
Nucleus
Nucleus Speckle
Localizes To The Centriole In Cells Lacking Cilia And To The Cilium Basal Body In Ciliated Cells
At The Exit Of Mitosis
When The Primary Cilium Is Reassembled In Daughter Cells
Localizes At The Mother Centriole That Acts As The Basal Body Of The Assembling Primary Cilium And Also Accumulates At The Ciliary Base That Constitutes A Diffusion Barrier For Ciliary Proteins
Alternative Antibody Names Anti-Cilium Assembly Protein Dzip1 antibody
Anti-Daz-Interacting Protein 1/2 antibody
Anti-Daz-Interacting Zinc Finger Protein 1 antibody
Anti-DZIP1 antibody
Anti-DZIP antibody
Anti-DZIP2 antibody
Anti-KIAA0996 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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