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  • 产品名称：Mouse LPCAT3 (Lysophosphatidylcholine Acyltransferase 3) Sandwich ELISA Kit (STJE0010399)

  • 产品型号：STJE0010399
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Mouse LPCAT3 (Lysophosphatidylcholine Acyltransferase 3) Sandwich ELISA Kit (STJE0010399)
详情介绍：
Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.061ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This LPCAT3 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Lpcat3
Gene ID: 14792
Uniprot ID: MBOA5_MOUSE
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Detected ubiquitously, with high expression levels in small intestine, brown adipose tissue, liver, kidney and testis. Expressed in liver and both proximal and distal small intestine (at protein level). Expressed in peritoneal macrophages.
Post Translational Modifications
Function Lysophospholipid O-acyltransferase (LPLAT) that catalyzes the reacylation step of the phospholipid remodeling process also known as the Lands cycle. Catalyzes transfer of the fatty acyl chain from fatty acyl-CoA to 1-acyl lysophospholipid to form various classes of phospholipids. Converts 1-acyl lysophosphatidylcholine (LPC) into phosphatidylcholine (PC) (LPCAT activity), 1-acyl lysophosphatidylserine (LPS) into phosphatidylserine (PS) (LPSAT activity) and 1-acyl lysophosphatidylethanolamine (LPE) into phosphatidylethanolamine (PE) (LPEAT activity). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs. Has higher activity for LPC acyl acceptors compared to LPEs and LPSs. Can also transfer the fatty acyl chain from fatty acyl-CoA to 1-O-alkyl lysophospholipid or 1-O-alkenyl lysophospholipid with lower efficiency. Acts as a major LPC O-acyltransferase in liver and intestine. As a component of the liver X receptor/NR1H3 or NR1H2 signaling pathway, mainly catalyzes the incorporation of arachidonate into PCs of endoplasmic reticulum (ER) membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Promotes processing of sterol regulatory protein SREBF1 in hepatocytes, likely by facilitating the translocation of SREBF1-SCAP complex from ER to the Golgi apparatus. Participates in mechanisms by which the liver X receptor/NR1H3 or NR1H2 signaling pathway counteracts lipid-induced ER stress response and inflammation. Down-regulates hepatic inflammation by limiting arachidonic acid availability for synthesis of inflammatory eicosanoids, such as prostaglandins. In enterocytes, acts as a component of a gut-brain feedback loop that coordinates dietary lipid absorption and food intake. Regulates the abundance of PCs containing linoleate and arachidonate in enterocyte membranes, enabling passive diffusion of fatty acids and cholesterol across the membrane for efficient chylomicron assembly. In the intestinal crypt, acts as a component of dietary-responsive phospholipid-cholesterol axis, regulating the biosynthesis of cholesterol and its mitogenic effects on intestinal stem cells.
Protein Name Lysophospholipid Acyltransferase 5
Lplat 5
1-Acylglycerophosphocholine O-Acyltransferase
1-Acylglycerophosphoethanolamine O-Acyltransferase
1-Acylglycerophosphoserine O-Acyltransferase
Lysophosphatidylcholine Acyltransferase
Lpcat
Lyso-Pc Acyltransferase
Lysophosphatidylcholine Acyltransferase 3
Lyso-Pc Acyltransferase 3
Mlpcat3
Lysophosphatidylethanolamine Acyltransferase
Lpeat
Lyso-Pe Acyltransferase
Lysophosphatidylserine Acyltransferase
Lpsat
Lyso-Ps Acyltransferase
Membrane-Bound O-Acyltransferase Domain-Containing Protein 5
O-Acyltransferase Domain-Containing Protein 5
Database Links Reactome: R-MMU-1482788
Reactome: -MMU-1482801
Reactome: -MMU-1482839
Cellular Localisation Endoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
Alternative ELISA Names Lysophospholipid Acyltransferase 5 ELISA kit
Lplat 5 ELISA kit
1-Acylglycerophosphocholine O-Acyltransferase ELISA kit
1-Acylglycerophosphoethanolamine O-Acyltransferase ELISA kit
1-Acylglycerophosphoserine O-Acyltransferase ELISA kit
Lysophosphatidylcholine Acyltransferase ELISA kit
Lpcat ELISA kit
Lyso-Pc Acyltransferase ELISA kit
Lysophosphatidylcholine Acyltransferase 3 ELISA kit
Lyso-Pc Acyltransferase 3 ELISA kit
Mlpcat3 ELISA kit
Lysophosphatidylethanolamine Acyltransferase ELISA kit
Lpeat ELISA kit
Lyso-Pe Acyltransferase ELISA kit
Lysophosphatidylserine Acyltransferase ELISA kit
Lpsat ELISA kit
Lyso-Ps Acyltransferase ELISA kit
Membrane-Bound O-Acyltransferase Domain-Containing Protein 5 ELISA kit
O-Acyltransferase Domain-Containing Protein 5 ELISA kit
Lpcat3 ELISA kit
Grcc3f ELISA kit
Mboat5 ELISA kit
Oact5 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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