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  • 产品名称：Anti-EFNA1 antibody (66-115 aa) (STJ92954)

  • 产品型号：STJ92954
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-EFNA1 antibody (66-115 aa) (STJ92954)
详情介绍：
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Ephrin-A1 (66-115 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EFNA1
Gene ID: 1942
Uniprot ID: EFNA1_HUMAN
Immunogen Region: 66-115 aa
Specificity: Ephrin-A1 Polyclonal Antibody detects endogenous levels of Ephrin-A1 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human EFNA1 at the amino acid range 66-115
Post Translational Modifications Undergoes proteolysis by a metalloprotease to give rise to a soluble monomeric form. N-Glycosylation is required for binding to EPHA2 receptor and inducing its internalization.
Function Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.
Protein Name Ephrin-A1
Eph-Related Receptor Tyrosine Kinase Ligand 1
Lerk-1
Immediate Early Response Protein B61
Tumor Necrosis Factor Alpha-Induced Protein 4
Tnf Alpha-Induced Protein 4 Cleaved Into - Ephrin-A1 - Secreted Form
Database Links Reactome: R-HSA-2682334
Reactome: R-HSA-3928663
Reactome: R-HSA-3928665
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Ephrin-A1
Secreted Form: Secreted
Alternative Antibody Names Anti-Ephrin-A1 antibody
Anti-Eph-Related Receptor Tyrosine Kinase Ligand 1 antibody
Anti-Lerk-1 antibody
Anti-Immediate Early Response Protein B61 antibody
Anti-Tumor Necrosis Factor Alpha-Induced Protein 4 antibody
Anti-Tnf Alpha-Induced Protein 4 Cleaved Into - Ephrin-A1 - Secreted Form antibody
Anti-EFNA1 antibody
Anti-EPLG1 antibody
Anti-LERK1 antibody
Anti-TNFAIP4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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