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  • 产品名称：Anti-EHMT2 antibody (370-450 aa) (STJ192390)

  • 产品型号：STJ192390
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-EHMT2 antibody (370-450 aa) (STJ192390)
详情介绍：
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Histone-lysine N-methyltransferase EHMT2 (370-450 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EHMT2
Gene ID: 10919
Uniprot ID: EHMT2_HUMAN
Immunogen Region: 370-450 aa
Specificity: EHMT2 Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from the human protein at the amino acid range 370-450
Post Translational Modifications Methylated at Lys-185.automethylated.
Function Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. Recruited to the promoters of target genes through interaction with transcriptional repressor MSX1, leading to the inhibition of myoblast differentiation via transcriptional repression of differentiation factors.
Protein Name Histone-Lysine N-Methyltransferase Ehmt2
Euchromatic Histone-Lysine N-Methyltransferase 2
Hla-B-Associated Transcript 8
Histone H3-K9 Methyltransferase 3
H3-K9-Hmtase 3
Lysine N-Methyltransferase 1c
Protein G9a
Database Links Reactome: R-HSA-2559582
Reactome: R-HSA-3214841
Reactome: R-HSA-427389
Reactome: R-HSA-6804760
Reactome: R-HSA-73762
Reactome: R-HSA-8853884
Reactome: R-HSA-8953750
Cellular Localisation Nucleus
Chromosome
Associates With Euchromatic Regions
Does Not Associate With Heterochromatin
Alternative Antibody Names Anti-Histone-Lysine N-Methyltransferase Ehmt2 antibody
Anti-Euchromatic Histone-Lysine N-Methyltransferase 2 antibody
Anti-Hla-B-Associated Transcript 8 antibody
Anti-Histone H3-K9 Methyltransferase 3 antibody
Anti-H3-K9-Hmtase 3 antibody
Anti-Lysine N-Methyltransferase 1c antibody
Anti-Protein G9a antibody
Anti-EHMT2 antibody
Anti-BAT8 antibody
Anti-C6orf30 antibody
Anti-G9A antibody
Anti-KMT1C antibody
Anti-NG36 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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