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  • 产品名称：Anti-EIF2AK4 antibody [S5120RM] (STJ11105120)

  • 产品型号：STJ11105120
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-EIF2AK4 antibody [S5120RM] (STJ11105120)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-Eif-2-Alpha Kinase Gcn2 is suitable for use in Western Blot research applications.
Clonality: Monoclonal
Clone ID: S5120RM
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EIF2AK4
Gene ID: 440275
Uniprot ID: E2AK4_HUMAN
Immunogen: Recombinant protein of human GCN2.
Tissue Specificity Widely expressed. Expressed in lung, smooth muscle cells and macrophages.
Post Translational Modifications Autophosphorylated.autophosphorylation on Thr-899 is increased upon amino acid starvation and in UV irradiation cells and inhibited in presence of IMPACT.
Function Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to low amino acid availability. Plays a role as an activator of the integrated stress response (ISR) required for adaptation to amino acid starvation. EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Binds uncharged tRNAs. Required for the translational induction of protein kinase PRKCH following amino acid starvation. Involved in cell cycle arrest by promoting cyclin D1 mRNA translation repression after the unfolded protein response pathway (UPR) activation or cell cycle inhibitor CDKN1A/p21 mRNA translation activation in response to amino acid deprivation. Plays a role in the consolidation of synaptic plasticity, learning as well as formation of long-term memory. Plays a role in neurite outgrowth inhibition. Plays a proapoptotic role in response to glucose deprivation. Promotes global cellular protein synthesis repression in response to UV irradiation independently of the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and p38 MAPK signaling pathways. Plays a role in the antiviral response against alphavirus infection.impairs early viral mRNA translation of the incoming genomic virus RNA, thus preventing alphavirus replication. (Microbial infection) Plays a role in modulating the adaptive immune response to yellow fever virus infection.promotes dendritic cells to initiate autophagy and antigene presentation to both CD4(+) and CD8(+) T-cells under amino acid starvation.
Protein Name Eif-2-Alpha Kinase Gcn2
Eukaryotic Translation Initiation Factor 2-Alpha Kinase 4
Gcn2-Like Protein
Database Links Reactome: R-HSA-9633012
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Eif-2-Alpha Kinase Gcn2 antibody
Anti-Eukaryotic Translation Initiation Factor 2-Alpha Kinase 4 antibody
Anti-Gcn2-Like Protein antibody
Anti-EIF2AK4 antibody
Anti-GCN2 antibody
Anti-KIAA1338 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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