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  • 产品名称：Anti-EIF4B antibody (209-259) (STJA0006725)

  • 产品型号：STJA0006725
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-EIF4B antibody (209-259) (STJA0006725)
详情介绍：
Host: Rabbit
Applications: IHC/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Eukaryotic translation initiation factor 4B (209-259) is suitable for use in Immunohistochemistry and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC-p1:50-200
WB 1:1000-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EIF4B
Gene ID: 1975
Uniprot ID: IF4B_HUMAN
Immunogen Region: 209-259
Specificity: This antibody detects endogenous levels of Eif4b at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human Eif4b AA range: 209-259
Post Translational Modifications Phosphorylated at Ser-422 by RPS6KA1 and RPS6KB1.phosphorylation enhances the affinity of EIF4B for the EIF3 complex. In response to mTORC1 activation, RPS6KA1-mediated phosphorylation at 'Ser-406' and 'Ser-422' stimulates bicarbonate cotransporter SLC4A7 mRNA translation, increasing SLC4A7 protein abundance and function.
Function Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
Protein Name Eukaryotic Translation Initiation Factor 4b
Eif-4b
Database Links Reactome: R-HSA-156827
Reactome: R-HSA-166208
Reactome: R-HSA-429947
Reactome: R-HSA-72649
Reactome: R-HSA-72662
Reactome: R-HSA-72702
Reactome: R-HSA-72706
Alternative Antibody Names Anti-Eukaryotic Translation Initiation Factor 4b antibody
Anti-Eif-4b antibody
Anti-EIF4B antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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