产品详情
查看大图

  • 产品名称：Anti-ENPP1 antibody (STJ193081)

  • 产品型号：STJ193081
  • 产品厂商：ST john's laboratory
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Anti-ENPP1 antibody (STJ193081)
详情介绍：
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ENPP1
Gene ID: 5167
Uniprot ID: ENPP1_HUMAN
Specificity: ENPP1 Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from part of the human protein
Post Translational Modifications Autophosphorylated as part of the catalytic cycle of phosphodiesterase/pyrophosphatase activity. N-glycosylated. The secreted form is produced through cleavage at Lys-103 by intracellular processing.
Function Nucleotide pyrophosphatase that generates diphosphate (PPi) and functions in bone mineralization and soft tissue calcification by regulating pyrophosphate levels. PPi inhibits bone mineralization and soft tissue calcification by binding to nascent hydroxyapatite crystals, thereby preventing further growth of these crystals. Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP and UTP to their corresponding monophosphates with release of pyrophosphate, as well as diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Inhibits ectopic joint calcification and maintains articular chondrocytes by repressing hedgehog signaling.it is however unclear whether hedgehog inhibition is direct or indirect. Appears to modulate insulin sensitivity and function. Also involved in melanogenesis. Also able to hydrolyze 2',3'-cGAMP (cyclic GMP-AMP), a second messenger that activates TMEM173/STING and triggers type-I interferon production. 2',3'-cGAMP degradation takes place in the lumen or extracellular space, and not in the cytosol where it is produced.the role of 2',3'-cGAMP hydrolysis is therefore unclear. Not able to hydrolyze the 2',3'-cGAMP linkage isomer 3'-3'-cGAMP.
Protein Name Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 1
E-Npp 1
Membrane Component Chromosome 6 Surface Marker 1
Phosphodiesterase I/Nucleotide Pyrophosphatase 1
Plasma-Cell Membrane Glycoprotein Pc-1 Cleaved Into - Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 1 - Secreted Form Includes - Alkaline Phosphodiesterase I - Nucleotide Pyrophosphatase
Nppase
Nucleotide Diphosphatase
Database Links Reactome: R-HSA-196843
Reactome: R-HSA-199220
Cellular Localisation Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 1: Cell Membrane
Single-Pass Type Ii Membrane Protein
Basolateral Cell Membrane
Targeted To The Basolateral Membrane In Polarized Epithelial Cells And In Hepatocytes
And To Matrix Vesicles In Osteoblasts
In Bile Duct Cells And Cancer Cells
Located To The Apical Cytoplasmic Side
Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 1
Secreted Form: Secreted
Secreted Following Proteolytic Cleavage
Alternative Antibody Names Anti-Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 1 antibody
Anti-E-Npp 1 antibody
Anti-Membrane Component Chromosome 6 Surface Marker 1 antibody
Anti-Phosphodiesterase I/Nucleotide Pyrophosphatase 1 antibody
Anti-Plasma-Cell Membrane Glycoprotein Pc-1 Cleaved Into - Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 1 - Secreted Form Includes - Alkaline Phosphodiesterase I - Nucleotide Pyrophosphatase antibody
Anti-Nppase antibody
Anti-Nucleotide Diphosphatase antibody
Anti-ENPP1 antibody
Anti-M6S1 antibody
Anti-NPPS antibody
Anti-PC1 antibody
Anti-PDNP1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
姓名：
电话：
您的需求：
 

沪公网安备 31011002002624号