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  • 产品名称：Anti-ENPP2 antibody (401-450 aa) (STJ96724)

  • 产品型号：STJ96724
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ENPP2 antibody (401-450 aa) (STJ96724)
详情介绍：
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (401-450 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
ELISA 1:20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ENPP2
Gene ID: 5168
Uniprot ID: ENPP2_HUMAN
Immunogen Region: 401-450 aa
Specificity: Autotaxin Polyclonal Antibody detects endogenous levels of Autotaxin protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human ENPP2 at the amino acid range 401-450
Post Translational Modifications N-glycosylation, but not furin-cleavage, plays a critical role on secretion and on lysoPLD activity. The interdomain disulfide bond between Cys-414 and Cys-806 is essential for catalytic activity.
Function Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Can also act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development (Probable). Tumor cell motility-stimulating factor. Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids. Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF).
Protein Name Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 2
E-Npp 2
Autotaxin
Extracellular Lysophospholipase D
Lysopld
Database Links Reactome: R-HSA-199220
Cellular Localisation Secreted
Alternative Antibody Names Anti-Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 2 antibody
Anti-E-Npp 2 antibody
Anti-Autotaxin antibody
Anti-Extracellular Lysophospholipase D antibody
Anti-Lysopld antibody
Anti-ENPP2 antibody
Anti-ATX antibody
Anti-PDNP2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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