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  • 产品名称：Anti-EPHA7 antibody (500-550) (STJ500924)

  • 产品型号：STJ500924-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-EPHA7 antibody (500-550) (STJ500924)
详情介绍：
Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-EPHA7 (500-550) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.50 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:200
IHC: 1:50-1:100
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: EPHA7
Gene ID: 2045
Uniprot ID: EPHA7_HUMAN
Immunogen Region: 500-550
Immunogen: Synthetic peptide corresponding taken within amino acid region 500-550 on human Ephrin type-A receptor 7 protein.
Tissue Specificity Widely expressed.
Post Translational Modifications Phosphorylated.
Function Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 and MAPK3 which are phosphorylated upon activation of EPHA7.
Protein Name Ephrin Type-A Receptor 7
Eph Homology Kinase 3
Ehk-3
Eph-Like Kinase 11
Ek11
Hek11
Database Links Reactome: R-HSA-2682334
Reactome: R-HSA-3928663
Reactome: R-HSA-3928665
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Ephrin Type-A Receptor 7 antibody
Anti-Eph Homology Kinase 3 antibody
Anti-Ehk-3 antibody
Anti-Eph-Like Kinase 11 antibody
Anti-Ek11 antibody
Anti-Hek11 antibody
Anti-EPHA7 antibody
Anti-EHK3 antibody
Anti-HEK11 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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