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  • 产品名称：Anti-EPHA8 antibody (STJ500927)

  • 产品型号：STJ500927-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-EPHA8 antibody (STJ500927)
详情介绍：
Host: Rabbit
Applications: ELISA/WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-EPHA8 is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.55-0.75 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: EPHA8
Gene ID: 2046
Uniprot ID: EPHA8_HUMAN
Immunogen: Synthetic peptide corresponding to unique amino acid sequences on human EphA R8 protein.
Function Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system also plays a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth.
Protein Name Ephrin Type-A Receptor 8
Eph- And Elk-Related Kinase
Eph-Like Kinase 3
Ek3
Hek3
Tyrosine-Protein Kinase Receptor Eek
Database Links Reactome: R-HSA-2682334
Reactome: R-HSA-3928663
Reactome: R-HSA-3928665
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Projection
Early Endosome Membrane
Undergoes Clathrin-Mediated Endocytosis Upon Efna5-Binding And Is Targeted To Early Endosomes
Alternative Antibody Names Anti-Ephrin Type-A Receptor 8 antibody
Anti-Eph- And Elk-Related Kinase antibody
Anti-Eph-Like Kinase 3 antibody
Anti-Ek3 antibody
Anti-Hek3 antibody
Anti-Tyrosine-Protein Kinase Receptor Eek antibody
Anti-EPHA8 antibody
Anti-EEK antibody
Anti-HEK3 antibody
Anti-KIAA1459 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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