产品详情
简单介绍：
Anti-ERCC3 antibody (513-782) (STJ23564)
详情介绍：
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-ERCC3 (513-782) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ERCC3 |
| Gene ID: | 2071 |
| Uniprot ID: | ERCC3_HUMAN |
| Immunogen Region: | 513-782 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 513-782 of human ERCC3 (NP_000113.1). |
| Immunogen Sequence: | PMSPEFYREYVAIKTKKRIL LYTMNPNKFRACQFLIKFHE RRNDKIIVFADNVFALKEYA IRLNKPYIYGPTSQGERMQI LQNFKHNPKINTIFISKVGD TSFDLPEANVLIQISSHGGS RRQEAQRLGRVLRAKKGMVA EEYNAFFYSLVSQDTQEMAY STKRQRFLVDQGYSFKVITK LAGMEEEDLAFSTKEEQQQL LQKVLAATDLDAEEEVVAGE FGSRSSQASRRFGTMSSMS |
| Function | ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. |
| Protein Name | General Transcription And Dna Repair Factor Iih Helicase Subunit Xpb Tfiih Subunit Xpb Basic Transcription Factor 2 89 Kda Subunit Btf2 P89 Dna Excision Repair Protein Ercc-3 Dna Repair Protein Complementing Xp-B Cells Tfiih Basal Transcription Factor Complex 89 Kda Subunit Tfiih 89 Kda Subunit Tfiih P89 Xeroderma Pigmentosum Group B-Complementing Protein |
| Database Links | Reactome: R-HSA-112382 Reactome: R-HSA-113418 Reactome: R-HSA-167152 Reactome: R-HSA-167158 Reactome: R-HSA-167160 Reactome: R-HSA-167161 Reactome: R-HSA-167162 Reactome: R-HSA-167172 Reactome: R-HSA-167200 Reactome: R-HSA-167246 Reactome: R-HSA-427413 Reactome: R-HSA-5696395 Reactome: R-HSA-5696400 Reactome: R-HSA-674695 Reactome: R-HSA-6781823 Reactome: R-HSA-6781827 Reactome: R-HSA-6782135 Reactome: R-HSA-6782210 Reactome: R-HSA-6796648 Reactome: R-HSA-72086 Reactome: R-HSA-73762 Reactome: R-HSA-73772 Reactome: R-HSA-73776 Reactome: R-HSA-73779 Reactome: R-HSA-73863 Reactome: R-HSA-75953 Reactome: R-HSA-75955 Reactome: R-HSA-76042 Reactome: R-HSA-77075 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-General Transcription And Dna Repair Factor Iih Helicase Subunit Xpb antibody Anti-Tfiih Subunit Xpb antibody Anti-Basic Transcription Factor 2 89 Kda Subunit antibody Anti-Btf2 P89 antibody Anti-Dna Excision Repair Protein Ercc-3 antibody Anti-Dna Repair Protein Complementing Xp-B Cells antibody Anti-Tfiih Basal Transcription Factor Complex 89 Kda Subunit antibody Anti-Tfiih 89 Kda Subunit antibody Anti-Tfiih P89 antibody Anti-Xeroderma Pigmentosum Group B-Complementing Protein antibody Anti-ERCC3 antibody Anti-XPB antibody Anti-XPBC antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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