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  • 产品名称：Anti-ERN1 antibody (STJA0010011)

  • 产品型号：STJA0010011
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ERN1 antibody (STJA0010011)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Serine/threonine-protein kinase/endoribonuclease IRE1 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ERN1
Gene ID: 2081
Uniprot ID: ERN1_HUMAN
Specificity: This antibody detects endogenous levels of IRE1 thr973 at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human IRE1 thr973
Tissue Specificity Ubiquitously expressed. High levels observed in pancreatic tissue.
Post Translational Modifications Autophosphorylated following homodimerization. Autophosphorylation promotes activation of the endoribonuclease domain. In response to ER stress, phosphorylated at Ser-724, Ser-729 and possibly Ser-726.phosphorylation promotes oligomerization and endoribonuclease activity. Dephosphorylated at Ser-724, Ser-729 and possibly Ser-726 by RPAP2 to abort failed ER-stress adaptation and trigger apoptosis. ADP-ribosylated by PARP16 upon ER stress, which increases both kinase and endonuclease activities.
Function Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR). In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP. Accumulation of misfolded proteins in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity. The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA. The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes. Acts as an upstream signal for ER stress-induced GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane by modulating the expression and localization of SEC16A.
Protein Name Serine/Threonine-Protein Kinase/Endoribonuclease Ire1
Endoplasmic Reticulum-To-Nucleus Signaling 1
Inositol-Requiring Protein 1
Hire1p
Ire1-Alpha
Ire1a Includes - Serine/Threonine-Protein Kinase - Endoribonuclease
Database Links Reactome: R-HSA-381070
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Serine/Threonine-Protein Kinase/Endoribonuclease Ire1 antibody
Anti-Endoplasmic Reticulum-To-Nucleus Signaling 1 antibody
Anti-Inositol-Requiring Protein 1 antibody
Anti-Hire1p antibody
Anti-Ire1-Alpha antibody
Anti-Ire1a Includes - Serine/Threonine-Protein Kinase - Endoribonuclease antibody
Anti-ERN1 antibody
Anti-IRE1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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