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  • 产品名称：Anti-ESR2 antibody (1-153) (STJ23576)

  • 产品型号：STJ23576
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ESR2 antibody (1-153) (STJ23576)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Estrogen Receptor beta (1-153) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:1000-1:5000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ESR2
Gene ID: 2100
Uniprot ID: ESR2_HUMAN
Immunogen Region: 1-153
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-153 of human Estrogen Receptor beta (NP_001428.1).
Immunogen Sequence: MDIKNSPSSLNSPSSYNCSQ SILPLEHGSIYIPSSYVDSH HEYPAMTFYSPAVMNYSIPS NVTNLEGGPGRQTTSPNVLW PTPGHLSPLVVHRQLSHLYA EPQKSPWCEARSLEHTLPVN RETLKRKVSGNRCASPVTGP GSKRDAHFCAVCS
Tissue Specificity Isoform 1: Expressed in testis and ovary, and at a lower level in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, prostate, colon, bone marrow, mammary gland and uterus. Also found in uterine bone, breast, and ovarian tumor cell lines, but not in colon and liver tumors. Isoform 2: Expressed in spleen, thymus, testis and ovary and at a lower level in skeletal muscle, prostate, colon, small intestine, leukocytes, bone marrow, mammary gland and uterus. Isoform 4: Expressed in the testis. Isoform 5: Expressed in testis, and at a lower level in spleen, thymus, ovary, mammary gland and uterus. Isoform 6: Expressed in testis, placenta, skeletal muscle, spleen and leukocytes, and at a lower level in heart, lung, liver, kidney, pancreas, thymus, prostate, colon, small intestine, bone marrow, mammary gland and uterus. Not expressed in brain.
Post Translational Modifications Phosphorylation at Ser-87 and Ser-105 recruits NCOA1.
Function Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform 2: Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability.
Protein Name Estrogen Receptor Beta
Er-Beta
Nuclear Receptor Subfamily 3 Group A Member 2
Database Links Reactome: R-HSA-1257604
Reactome: R-HSA-2219530
Reactome: R-HSA-383280
Reactome: R-HSA-6811558
Reactome: R-HSA-8939211
Reactome: R-HSA-9009391
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Estrogen Receptor Beta antibody
Anti-Er-Beta antibody
Anti-Nuclear Receptor Subfamily 3 Group A Member 2 antibody
Anti-ESR2 antibody
Anti-ESTRB antibody
Anti-NR3A2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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