产品详情
查看大图

  • 产品名称：Anti-ESRRA antibody (1-76) (STJ23577)

  • 产品型号：STJ23577
  • 产品厂商：ST john's laboratory
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Anti-ESRRA antibody (1-76) (STJ23577)
详情介绍：
Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ESRRA (1-76) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ESRRA
Gene ID: 2101
Uniprot ID: ERR1_HUMAN
Immunogen Region: 1-76
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-76 of human ESRRA (NP_004442.3).
Immunogen Sequence: MSSQVVGIEPLYIKAEPASP DSPKGSSETETEPPVALAPG PAPTRCLPGHKEEEDGEGAG PGEQGGGKLVLSSLPK
Post Translational Modifications Phosphorylation on Ser-19 enhances sumoylation on Lys-14 increasing repression of transcriptional activity. Sumoylated with SUMO2. Main site is Lys-14 which is enhanced by phosphorylation on Ser-19, cofactor activation, and by interaction with PIAS4. Sumoylation enhances repression of transcriptional activity, but has no effect on subcellular location nor on DNA binding. Reversibly acetylated. Acetylation by PCAF/KAT2 at Lys-129, Lys-138, Lys-160 and Lys-162 and PCAF/KAT2 decreases transcriptional activity probably by inhibiting DNA-binding activity.deacetylation involves SIRT1 and HDAC8 and increases DNA-binding.
Function Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.
Protein Name Steroid Hormone Receptor Err1
Estrogen Receptor-Like 1
Estrogen-Related Receptor Alpha
Err-Alpha
Nuclear Receptor Subfamily 3 Group B Member 1
Database Links Reactome: R-HSA-1989781
Reactome: R-HSA-2151201
Reactome: R-HSA-383280
Reactome: R-HSA-8939902
Cellular Localisation Nucleus
Cytoplasm
Co-Localizes To The Cytoplasm Only In Presence Of Mapk15
Alternative Antibody Names Anti-Steroid Hormone Receptor Err1 antibody
Anti-Estrogen Receptor-Like 1 antibody
Anti-Estrogen-Related Receptor Alpha antibody
Anti-Err-Alpha antibody
Anti-Nuclear Receptor Subfamily 3 Group B Member 1 antibody
Anti-ESRRA antibody
Anti-ERR1 antibody
Anti-ESRL1 antibody
Anti-NR3B1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
姓名：
电话：
您的需求：
 

沪公网安备 31011002002624号