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  • 产品名称：Anti-EYA3 antibody (1-300) (STJ117250)

  • 产品型号：STJ117250
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-EYA3 antibody (1-300) (STJ117250)
详情介绍：
Host: Rabbit
Applications: WB/IF
Reactivity: Human/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-EYA3 (1-300) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EYA3
Gene ID: 2140
Uniprot ID: EYA3_HUMAN
Immunogen Region: 1-300
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human EYA3 (NP_001981.2).
Immunogen Sequence: MEEEQDLPEQPVKKAKMQES GEQTISQVSNPDVSDQKPET SSLASNLPMSEEIMTCTDYI PRSSNDYTSQMYSAKPYAHI LSVPVSETAYPGQTQYQTLQ QTQPYAVYPQATQTYGLPPF GALWPGMKPESGLIQTPSPS QHSVLTCTTGLTTSQPSPAH YSYPIQASSTNASLISTSST IANIPAAAVASISNQDYPTY TILGQNQYQACYPSSSFGVT GQTNSDAESTTLAATTYQS
Post Translational Modifications Ser-266 phosphorylation is required for localization at sites of DNA damage and directing interaction with H2AX.
Function Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity. May be involved in development of the eye.
Protein Name Eyes Absent Homolog 3
Database Links Reactome: R-HSA-5693565
Cellular Localisation Cytoplasm
Nucleus
Localizes At Sites Of Dna Damage At Double-Strand Breaks (Dsbs)
With Decreasing Efficiency
Translocalized To The Nucleus By Six2 And Six5
And Six4
Respectively
Alternative Antibody Names Anti-Eyes Absent Homolog 3 antibody
Anti-EYA3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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