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  • 产品名称：Anti-F11R antibody (191-240 aa) (STJ96844)

  • 产品型号：STJ96844
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-F11R antibody (191-240 aa) (STJ96844)
详情介绍：
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Junctional adhesion molecule A (191-240 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC-P 1:100-1:300
ELISA 1:20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: F11R
Gene ID: 50848
Uniprot ID: JAM1_HUMAN
Immunogen Region: 191-240 aa
Specificity: JAM-A Polyclonal Antibody detects endogenous levels of JAM-A protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human F11R at the amino acid range 191-240
Post Translational Modifications N-glycosylated. (Microbial infection) Cleaved by H.pylori virulence factor PqqE. Cleavage leads to altered tight junction functions.
Function Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation. (Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1. (Microbial infection) Acts as a receptor for Human Rotavirus strain Wa.
Protein Name Junctional Adhesion Molecule A
Jam-A
Junctional Adhesion Molecule 1
Jam-1
Platelet F11 Receptor
Platelet Adhesion Molecule 1
Pam-1
Cd Antigen Cd321
Database Links Reactome: R-HSA-202733
Reactome: R-HSA-216083
Reactome: R-HSA-2173791
Reactome: R-HSA-420029
Cellular Localisation Cell Junction
Tight Junction
Cell Membrane
Single-Pass Type I Membrane Protein
Localized At Tight Junctions Of Both Epithelial And Endothelial Cells
Alternative Antibody Names Anti-Junctional Adhesion Molecule A antibody
Anti-Jam-A antibody
Anti-Junctional Adhesion Molecule 1 antibody
Anti-Jam-1 antibody
Anti-Platelet F11 Receptor antibody
Anti-Platelet Adhesion Molecule 1 antibody
Anti-Pam-1 antibody
Anti-Cd Antigen Cd321 antibody
Anti-F11R antibody
Anti-JAM1 antibody
Anti-JCAM antibody
Anti-UNQ264 antibody
Anti-PRO301 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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