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  • 产品名称：Anti-CD8a antibody [IBL-3/25] (STJ16102636)

  • 产品型号：STJ16102636
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CD8a antibody [IBL-3/25] (STJ16102636)
详情介绍：
Host: Rat
Applications: FC/IF/IHC
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rat monoclonal antibody anti-CD8a is suitable for use in Flow Cytometry, Immunofluorescence and Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: IBL-3/25
Conjugation: Unconjugated
Isotype: IgGk
Formulation: PBS with 0.02% Sodium Azide.
Purification: Affinity purified from tissue culture.
Concentration: Can be provided as 100 µg/mL, 500 µg/mL or 1mg/mL.
Dilution Range: Flow cytometry (0, 5-1, 0 µg/million cells in 0, 1 ml). Immunofluorescence (0, 5-1, 0 µg/ml). Immunohistology (1-2 µg/ml for 30 min at RT; an appropriate antigen retrieval method for staining of formalin-fixed tissues has not been established to date
Storage Instruction: Store for up to 1 year at 2-8°C upon receipt.
Gene Symbol: Cd8a
Gene ID: 12525
Uniprot ID: CD8A_MOUSE
Immunogen: A Wistar rat was immunized with mouse lymph node cells. Fusion partner: SP-2/0.
Function Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
Protein Name T-Cell Surface Glycoprotein Cd8 Alpha Chain
T-Cell Surface Glycoprotein Lyt-2
Cd Antigen Cd8a
Database Links Reactome: R-MMU-198933
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cd8a Localizes To Lipid Rafts Only When Associated With Its Partner Cd8b
Alternative Antibody Names Anti-T-Cell Surface Glycoprotein Cd8 Alpha Chain antibody
Anti-T-Cell Surface Glycoprotein Lyt-2 antibody
Anti-Cd Antigen Cd8a antibody
Anti-Cd8a antibody
Anti-Lyt-2 antibody
Anti-Lyt2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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