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  • 产品名称：Anti-FADD antibody [7C4-F12-F1] (STJ99305)

  • 产品型号：STJ99305
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-FADD antibody [7C4-F12-F1] (STJ99305)
详情介绍：
Host: Mouse
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-FAS-associated death domain protein is suitable for use in Western Blot research applications.
Clonality: Monoclonal
Clone ID: 7C4-F12-F1
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FADD
Gene ID: 8772
Uniprot ID: FADD_HUMAN
Specificity: This antibody detects endogenous levels of FADD and does not cross-react with related proteins.
Immunogen: Purified recombinant human FADD protein fragments expressed in E.coli.
Post Translational Modifications (Microbial infection) Glycosylated at Arg-117 by enteropathogenic E.coli protein NleB1, C.rodentium protein NleB and S.typhimurium protein Ssek1: arginine GlcNAcylation prevents recruitment of caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors.
Function Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
Protein Name Fas-Associated Death Domain Protein
Fas-Associating Death Domain-Containing Protein
Growth-Inhibiting Gene 3 Protein
Mediator Of Receptor Induced Toxicity
Database Links Reactome: R-HSA-140534
Reactome: R-HSA-2562578
Reactome: R-HSA-3371378
Reactome: R-HSA-5213460
Reactome: R-HSA-5218900
Reactome: R-HSA-5357786
Reactome: R-HSA-5357905
Reactome: R-HSA-5675482
Reactome: R-HSA-69416
Reactome: R-HSA-75157
Reactome: R-HSA-75158
Reactome: R-HSA-9013957
Reactome: R-HSA-933543
Reactome: R-HSA-9693928
Alternative Antibody Names Anti-Fas-Associated Death Domain Protein antibody
Anti-Fas-Associating Death Domain-Containing Protein antibody
Anti-Growth-Inhibiting Gene 3 Protein antibody
Anti-Mediator Of Receptor Induced Toxicity antibody
Anti-FADD antibody
Anti-MORT1 antibody
Anti-GIG3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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