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  • 产品名称：Mouse TREM1 (Triggering Receptor Expressed On Myeloid Cells 1) Sandwich ELISA Kit (STJE0007183)

  • 产品型号：STJE0007183
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Mouse TREM1 (Triggering Receptor Expressed On Myeloid Cells 1) Sandwich ELISA Kit (STJE0007183)
详情介绍：
Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 5.4pg/mL
Detection Limit: 15.6-1000pg/mL
Short Description: This TREM1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Trem1
Gene ID: 58217
Uniprot ID: TREM1_MOUSE
Sample Type: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Tissue Specificity
Post Translational Modifications
Function Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses. Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12. In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma. This cascade promotes the neutrophil- and macrophage-mediated release of pro-inflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections. By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis.
Protein Name Triggering Receptor Expressed On Myeloid Cells 1
Trem-1
Cd Antigen Cd354
Database Links Reactome: R-MMU-198933
Reactome: -MMU-202733
Reactome: -MMU-2172127
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Recruited To Lipid Rafts When Activated
Alternative ELISA Names Triggering Receptor Expressed On Myeloid Cells 1 ELISA kit
Trem-1 ELISA kit
Cd Antigen Cd354 ELISA kit
Trem1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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