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  • 产品名称：Anti-CYP46A1 antibody (180-260 aa) (STJ190286)

  • 产品型号：STJ190286
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CYP46A1 antibody (180-260 aa) (STJ190286)
详情介绍：
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Cholesterol 24-hydroxylase (180-260 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CYP46A1
Gene ID: 10858
Uniprot ID: CP46A_HUMAN
Immunogen Region: 180-260 aa
Specificity: CP46A Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from the human protein at the amino acid range 180-260
Function P450 monooxygenase that plays a major role in cholesterol homeostasis in the brain. Primarily catalyzes the hydroxylation (with S stereochemistry) at C-24 of cholesterol side chain, triggering cholesterol diffusion out of neurons and its further degradation. By promoting constant cholesterol elimination in neurons, may activate the mevalonate pathway and coordinate the synthesis of new cholesterol and nonsterol isoprenoids involved in synaptic activity and learning. Further hydroxylates cholesterol derivatives and hormone steroids on both the ring and side chain of these molecules, converting them into active oxysterols involved in lipid signaling and biosynthesis. Acts as an epoxidase converting cholesta-5,24-dien-3beta-ol/desmosterol into (24S),25-epoxycholesterol, an abundant lipid ligand of nuclear NR1H2 and NR1H3 receptors shown to promote neurogenesis in developing brain. May also catalyze the oxidative metabolism of xenobiotics, such as clotrimazole.
Protein Name Cholesterol 24-Hydroxylase
Ch24h
Cholesterol 24-Monooxygenase
Cholesterol 24s-Hydroxylase
Cytochrome P450 46a1
Database Links Reactome: R-HSA-193775
Reactome: R-HSA-211976
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Membrane Protein
Microsome Membrane
Postsynapse
Presynapse
Cell Projection
Dendrite
Alternative Antibody Names Anti-Cholesterol 24-Hydroxylase antibody
Anti-Ch24h antibody
Anti-Cholesterol 24-Monooxygenase antibody
Anti-Cholesterol 24s-Hydroxylase antibody
Anti-Cytochrome P450 46a1 antibody
Anti-CYP46A1 antibody
Anti-CYP46 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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