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  • 产品名称：Anti-DEFA5 antibody (STJA0008550)

  • 产品型号：STJA0008550
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-DEFA5 antibody (STJA0008550)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Defensin alpha 5 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DEFA5
Gene ID: 1670
Uniprot ID: DEF5_HUMAN
Specificity: This antibody detects endogenous levels of DEFA5 at Human, Rat
Immunogen: Synthesized peptide derived from human DEFA5
Post Translational Modifications Glycosylated. Proteolytically cleaved at Arg-62 by trypsin. Both the propeptide form proHD5/HD5(20-94) and HD5(56-94) are cleaved into the lumenal peptide form HD5(63-94) by trypsin. Unprocessed proHD5 exerts antimicrobial activities, but peptide potency is enhanced by peptide processing. Proteolytically cleaved in duodenal fluid.derived fragments are antimicrobially active against commensal bacteria (in vitro). (Microbial infection) The disulfide bridges and homodimerization are a prerequisite for the enhancement of S.flexneri adhesion and invasion.
Function Host-defense peptide that maintains sterility in the urogenital system. Has antimicrobial activity against a wide range of bacteria, including Gram-negative E.coli, P.aeruginosa and S.typhimurium, and Gram-positive E.aerogenes, S.aureus, B.cereus, E.faecium and L.monocytogenes. Confers resistance to intestinal infection by S.typhimurium. Exhibits antimicrobial activity against enteric commensal bacteria such as B.adolescentis, L.acidophilus, B.breve, L.fermentum, B.longum and S.thermophilus. Binds to bacterial membranes and causes membrane disintegration. Induces the secretion of the chemokine IL-8 by intestinal epithelial cells. Binds to B.antracis lef/lethal factor, a major virulence factor from B.anthracis, and neutralizes its enzymatic activity. (Microbial infection) Acts as a target for S.flexneri infection by binding to the bacterium, possibly via bacterial surface proteins, and thereby augmenting infectivity via enhanced bacterial adhesion and invasion of epithelial cells and tissues.
Protein Name Defensin Alpha 5
Defensin-5
Hd5(20-94 Cleaved Into - Hd5(23-94 - Hd5(29-94 - Hd5(56-94 - Hd5(63-94
Database Links Reactome: R-HSA-1461973
Reactome: R-HSA-1462054
Cellular Localisation Secreted
Cytoplasmic Vesicle
Secretory Vesicle
Stored As Propeptide Hd5(20-94) In Secretory Granules Of Small Intestinal Paneth Cells And Found In The Ileum Lumen As Processed Mature Peptides
Predominantly In The Hd5(63-94) Form
Peptides Hd5(20-94)
Hd5(23-94) And Hd5(29-94) Are Found Within Tissues
Hd5(20-94) Being The Predominant Intracellular Form
Peptides Hd5(56-94) And Hd5(63-94) Are Found In The Extracellular Milieu
Hd5(63-94) Being The Most Abundant Form
Secreted Into The Female Genital Tract Lumen
Alternative Antibody Names Anti-Defensin Alpha 5 antibody
Anti-Defensin-5 antibody
Anti-Hd5(20-94 Cleaved Into - Hd5(23-94 - Hd5(29-94 - Hd5(56-94 - Hd5(63-94 antibody
Anti-DEFA5 antibody
Anti-DEF5 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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