产品详情
简单介绍:
Anti-DEFA5 antibody (STJA0008550)
详情介绍:
Host: | Rabbit |
Applications: | WB |
Reactivity: | Human/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-Defensin alpha 5 is suitable for use in Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500-2000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | DEFA5 |
Gene ID: | 1670 |
Uniprot ID: | DEF5_HUMAN |
Specificity: | This antibody detects endogenous levels of DEFA5 at Human, Rat |
Immunogen: | Synthesized peptide derived from human DEFA5 |
Post Translational Modifications | Glycosylated. Proteolytically cleaved at Arg-62 by trypsin. Both the propeptide form proHD5/HD5(20-94) and HD5(56-94) are cleaved into the lumenal peptide form HD5(63-94) by trypsin. Unprocessed proHD5 exerts antimicrobial activities, but peptide potency is enhanced by peptide processing. Proteolytically cleaved in duodenal fluid.derived fragments are antimicrobially active against commensal bacteria (in vitro). (Microbial infection) The disulfide bridges and homodimerization are a prerequisite for the enhancement of S.flexneri adhesion and invasion. |
Function | Host-defense peptide that maintains sterility in the urogenital system. Has antimicrobial activity against a wide range of bacteria, including Gram-negative E.coli, P.aeruginosa and S.typhimurium, and Gram-positive E.aerogenes, S.aureus, B.cereus, E.faecium and L.monocytogenes. Confers resistance to intestinal infection by S.typhimurium. Exhibits antimicrobial activity against enteric commensal bacteria such as B.adolescentis, L.acidophilus, B.breve, L.fermentum, B.longum and S.thermophilus. Binds to bacterial membranes and causes membrane disintegration. Induces the secretion of the chemokine IL-8 by intestinal epithelial cells. Binds to B.antracis lef/lethal factor, a major virulence factor from B.anthracis, and neutralizes its enzymatic activity. (Microbial infection) Acts as a target for S.flexneri infection by binding to the bacterium, possibly via bacterial surface proteins, and thereby augmenting infectivity via enhanced bacterial adhesion and invasion of epithelial cells and tissues. |
Protein Name | Defensin Alpha 5 Defensin-5 Hd5(20-94 Cleaved Into - Hd5(23-94 - Hd5(29-94 - Hd5(56-94 - Hd5(63-94 |
Database Links | Reactome: R-HSA-1461973 Reactome: R-HSA-1462054 |
Cellular Localisation | Secreted Cytoplasmic Vesicle Secretory Vesicle Stored As Propeptide Hd5(20-94) In Secretory Granules Of Small Intestinal Paneth Cells And Found In The Ileum Lumen As Processed Mature Peptides Predominantly In The Hd5(63-94) Form Peptides Hd5(20-94) Hd5(23-94) And Hd5(29-94) Are Found Within Tissues Hd5(20-94) Being The Predominant Intracellular Form Peptides Hd5(56-94) And Hd5(63-94) Are Found In The Extracellular Milieu Hd5(63-94) Being The Most Abundant Form Secreted Into The Female Genital Tract Lumen |
Alternative Antibody Names | Anti-Defensin Alpha 5 antibody Anti-Defensin-5 antibody Anti-Hd5(20-94 Cleaved Into - Hd5(23-94 - Hd5(29-94 - Hd5(56-94 - Hd5(63-94 antibody Anti-DEFA5 antibody Anti-DEF5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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