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  • 产品名称：Anti-DYRK1A antibody (624-763) (STJ110998)

  • 产品型号：STJ110998
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-DYRK1A antibody (624-763) (STJ110998)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-DYRK1A (624-763) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DYRK1A
Gene ID: 1859
Uniprot ID: DYR1A_HUMAN
Immunogen Region: 624-763
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 624-763 of human DYRK1A (NP_001387.2).
Immunogen Sequence: LGNRTRPRVYNSPTNSSSTQ DSMEVGHSHHSMTSLSSSTT SSSTSSSSTGNQGNQAYQNR PVAANTLDFGQNGAMDVNLT VYSNPRQETGIAGHPTYQFS ANTGPAHYMTEGHLTMRQGA DREESPMTGVCVQQSPVASS
Tissue Specificity Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.
Post Translational Modifications Autophosphorylated on numerous tyrosine residues. Can also autophosphorylate on serine and threonine residues (in vitro).
Function Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Plays an important role in double-strand breaks (DSBs) repair following DNA damage. Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR). Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits p53/TP53 activity and apoptosis. Phosphorylates SEPTIN4, SEPTIN5 and SF3B1 at 'Thr-434'.
Protein Name Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1a
Dual Specificity Yak1-Related Kinase
Hp86
Protein Kinase Minibrain Homolog
Mnbh
Hmnb
Database Links Reactome: R-HSA-1538133
Cellular Localisation Nucleus
Nucleus Speckle
Alternative Antibody Names Anti-Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1a antibody
Anti-Dual Specificity Yak1-Related Kinase antibody
Anti-Hp86 antibody
Anti-Protein Kinase Minibrain Homolog antibody
Anti-Mnbh antibody
Anti-Hmnb antibody
Anti-DYRK1A antibody
Anti-DYRK antibody
Anti-MNB antibody
Anti-MNBH antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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