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  • 产品名称：Mouse LDLRAP1 (Low Density Lipoprotein Receptor Adaptor Protein 1) Sandwich ELISA Kit (STJE0010298)

  • 产品型号：STJE0010298
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Mouse LDLRAP1 (Low Density Lipoprotein Receptor Adaptor Protein 1) Sandwich ELISA Kit (STJE0010298)
详情介绍：
Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.067ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This LDLRAP1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Ldlrap1
Gene ID: 100017
Uniprot ID: ARH_MOUSE
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity
Post Translational Modifications
Function Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytosis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression.
Protein Name Low Density Lipoprotein Receptor Adapter Protein 1
Autosomal Recessive Hypercholesterolemia Protein Homolog
Database Links Reactome: R-MMU-8856825
Reactome: -MMU-8856828
Reactome: -MMU-8964026
Reactome: -MMU-8964038
Reactome: -MMU-9758890
Cellular Localisation Cytoplasm
Alternative ELISA Names Low Density Lipoprotein Receptor Adapter Protein 1 ELISA kit
Autosomal Recessive Hypercholesterolemia Protein Homolog ELISA kit
Ldlrap1 ELISA kit
Arh ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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